STRINGSTRING
lexA protein (Geobacillus sp. WCH70) - STRING interaction network
"lexA" - LexA repressor in Geobacillus sp. WCH70
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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lexALexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (207 aa)    
Predicted Functional Partners:
ACS24050.1
KEGG- gtn-GTNG_1149 RecA2 protein; TIGRFAM- recA protein; PFAM- RecA domain protein; Belongs to the RecA family (283 aa)
   
 
  0.840
ACS24090.1
PFAM- Peptidoglycan-binding LysM; SMART- Peptidoglycan-binding LysM; KEGG- gtn-GTNG_1184 hypothetical protein (101 aa)
         
  0.831
dinB
DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3’-5’ exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (414 aa)
   
 
  0.811
dinG
ATP-dependent helicase DinG homolog; Probable helicase involved in DNA repair and perhaps also replication (921 aa)
   
   
  0.764
ACS24091.1
PFAM- Resolvase domain; KEGG- gka-GK1330 resolvase (217 aa)
   
   
  0.752
ACS25020.1
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA (573 aa)
     
 
  0.720
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (878 aa)
   
   
  0.693
birA
Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor (329 aa)
   
     
  0.688
hrcA
Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (344 aa)
   
     
  0.679
cinA
TIGRFAM- competence/damage-inducible protein CinA; molybdenum cofactor synthesis domain protein; PFAM- CinA domain protein; molybdopterin binding domain; KEGG- gka-GK1294 competence damage-inducible protein A (416 aa)
         
  0.663
Your Current Organism:
Geobacillus sp. WCH70
NCBI taxonomy Id: 471223
Other names: G. sp. WCH70, Geobacillus sp. WCH70
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