STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)    
Predicted Functional Partners:
ACS24377.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
 
 0.999
tdk
PFAM: thymidine kinase; KEGG: gtn:GTNG_3325 thymidine kinase.
  
 
 0.968
ACS23599.1
PFAM: homocysteine S-methyltransferase; methylenetetrahydrofolate reductase; KEGG: gka:GK0717 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein.
  
 
 0.945
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.942
folD
Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.939
ACS25146.1
TIGRFAM: ComE operon protein 2; PFAM: CMP/dCMP deaminase zinc-binding; KEGG: gka:GK2516 late competence protein (DNA binding and uptake).
  
 
 0.938
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.937
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
    
 0.926
ACS25591.1
PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: gka:GK2983 hypothetical protein; Belongs to the 5'-nucleotidase family.
    
  0.914
ACS25267.1
TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; KEGG: gtn:GTNG_2566 folylpolyglutamate synthase.
     
 0.847
Your Current Organism:
Geobacillus sp. WCH70
NCBI taxonomy Id: 471223
Other names: G. sp. WCH70
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