node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bcav_0095 | Bcav_0097 | Bcav_0095 | Bcav_0097 | PFAM: Glutaredoxin; TIGRFAM: Glutaredoxin-like protein NrdH. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.990 |
Bcav_0095 | Bcav_0099 | Bcav_0095 | Bcav_0099 | PFAM: Glutaredoxin; TIGRFAM: Glutaredoxin-like protein NrdH. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.981 |
Bcav_0095 | nrdI | Bcav_0095 | Bcav_0096 | PFAM: Glutaredoxin; TIGRFAM: Glutaredoxin-like protein NrdH. | NrdI protein; Probably involved in ribonucleotide reductase function. | 0.989 |
Bcav_0095 | nrdR | Bcav_0095 | Bcav_2431 | PFAM: Glutaredoxin; TIGRFAM: Glutaredoxin-like protein NrdH. | ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.473 |
Bcav_0097 | Bcav_0095 | Bcav_0097 | Bcav_0095 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | PFAM: Glutaredoxin; TIGRFAM: Glutaredoxin-like protein NrdH. | 0.990 |
Bcav_0097 | Bcav_0099 | Bcav_0097 | Bcav_0099 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.999 |
Bcav_0097 | nrdI | Bcav_0097 | Bcav_0096 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | NrdI protein; Probably involved in ribonucleotide reductase function. | 0.999 |
Bcav_0097 | nrdR | Bcav_0097 | Bcav_2431 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.661 |
Bcav_0099 | Bcav_0095 | Bcav_0099 | Bcav_0095 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | PFAM: Glutaredoxin; TIGRFAM: Glutaredoxin-like protein NrdH. | 0.981 |
Bcav_0099 | Bcav_0097 | Bcav_0099 | Bcav_0097 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.999 |
Bcav_0099 | nrdI | Bcav_0099 | Bcav_0096 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | NrdI protein; Probably involved in ribonucleotide reductase function. | 0.999 |
Bcav_0099 | nrdR | Bcav_0099 | Bcav_2431 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.625 |
Bcav_0568 | nrdR | Bcav_0568 | Bcav_2431 | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. | ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.454 |
Bcav_2430 | nrdR | Bcav_2430 | Bcav_2431 | Hypothetical protein. | ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.457 |
Bcav_2432 | lexA | Bcav_2432 | Bcav_2433 | PFAM: LysM domain. | SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.688 |
Bcav_2432 | nrdR | Bcav_2432 | Bcav_2431 | PFAM: LysM domain. | ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.583 |
Bcav_2742 | nadE | Bcav_2742 | Bcav_1848 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.825 |
Bcav_2742 | nrdR | Bcav_2742 | Bcav_2431 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.448 |
lexA | Bcav_2432 | Bcav_2433 | Bcav_2432 | SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | PFAM: LysM domain. | 0.688 |
lexA | nrdR | Bcav_2433 | Bcav_2431 | SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.682 |