node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bcav_3020 | Bcav_3706 | Bcav_3020 | Bcav_3706 | PFAM: Clp amino terminal domain. | PFAM: MerR family regulatory protein. | 0.425 |
Bcav_3020 | Bcav_3707 | Bcav_3020 | Bcav_3707 | PFAM: Clp amino terminal domain. | PFAM: DnaJ C terminal region; DnaJ domain. | 0.752 |
Bcav_3020 | dnaJ | Bcav_3020 | Bcav_1749 | PFAM: Clp amino terminal domain. | Chaperone DnaJ domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between [...] | 0.752 |
Bcav_3020 | dnaK | Bcav_3020 | Bcav_3709 | PFAM: Clp amino terminal domain. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.966 |
Bcav_3020 | groL | Bcav_3020 | Bcav_0821 | PFAM: Clp amino terminal domain. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.680 |
Bcav_3020 | groS | Bcav_3020 | Bcav_3058 | PFAM: Clp amino terminal domain. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.712 |
Bcav_3020 | grpE | Bcav_3020 | Bcav_3708 | PFAM: Clp amino terminal domain. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.845 |
Bcav_3020 | hrcA | Bcav_3020 | Bcav_1748 | PFAM: Clp amino terminal domain. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.617 |
Bcav_3404 | Bcav_3706 | Bcav_3404 | Bcav_3706 | ATPase AAA-2 domain protein; PFAM: ATPase family associated with various cellular activities (AAA); Clp amino terminal domain; C-terminal, D2-small domain, of ClpB protein; ATPase family associated with various cellular activities (AAA); Belongs to the ClpA/ClpB family. | PFAM: MerR family regulatory protein. | 0.425 |
Bcav_3404 | Bcav_3707 | Bcav_3404 | Bcav_3707 | ATPase AAA-2 domain protein; PFAM: ATPase family associated with various cellular activities (AAA); Clp amino terminal domain; C-terminal, D2-small domain, of ClpB protein; ATPase family associated with various cellular activities (AAA); Belongs to the ClpA/ClpB family. | PFAM: DnaJ C terminal region; DnaJ domain. | 0.752 |
Bcav_3404 | dnaJ | Bcav_3404 | Bcav_1749 | ATPase AAA-2 domain protein; PFAM: ATPase family associated with various cellular activities (AAA); Clp amino terminal domain; C-terminal, D2-small domain, of ClpB protein; ATPase family associated with various cellular activities (AAA); Belongs to the ClpA/ClpB family. | Chaperone DnaJ domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between [...] | 0.752 |
Bcav_3404 | dnaK | Bcav_3404 | Bcav_3709 | ATPase AAA-2 domain protein; PFAM: ATPase family associated with various cellular activities (AAA); Clp amino terminal domain; C-terminal, D2-small domain, of ClpB protein; ATPase family associated with various cellular activities (AAA); Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.966 |
Bcav_3404 | groL | Bcav_3404 | Bcav_0821 | ATPase AAA-2 domain protein; PFAM: ATPase family associated with various cellular activities (AAA); Clp amino terminal domain; C-terminal, D2-small domain, of ClpB protein; ATPase family associated with various cellular activities (AAA); Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.680 |
Bcav_3404 | groS | Bcav_3404 | Bcav_3058 | ATPase AAA-2 domain protein; PFAM: ATPase family associated with various cellular activities (AAA); Clp amino terminal domain; C-terminal, D2-small domain, of ClpB protein; ATPase family associated with various cellular activities (AAA); Belongs to the ClpA/ClpB family. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.712 |
Bcav_3404 | grpE | Bcav_3404 | Bcav_3708 | ATPase AAA-2 domain protein; PFAM: ATPase family associated with various cellular activities (AAA); Clp amino terminal domain; C-terminal, D2-small domain, of ClpB protein; ATPase family associated with various cellular activities (AAA); Belongs to the ClpA/ClpB family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.845 |
Bcav_3404 | hrcA | Bcav_3404 | Bcav_1748 | ATPase AAA-2 domain protein; PFAM: ATPase family associated with various cellular activities (AAA); Clp amino terminal domain; C-terminal, D2-small domain, of ClpB protein; ATPase family associated with various cellular activities (AAA); Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.640 |
Bcav_3706 | Bcav_3020 | Bcav_3706 | Bcav_3020 | PFAM: MerR family regulatory protein. | PFAM: Clp amino terminal domain. | 0.425 |
Bcav_3706 | Bcav_3404 | Bcav_3706 | Bcav_3404 | PFAM: MerR family regulatory protein. | ATPase AAA-2 domain protein; PFAM: ATPase family associated with various cellular activities (AAA); Clp amino terminal domain; C-terminal, D2-small domain, of ClpB protein; ATPase family associated with various cellular activities (AAA); Belongs to the ClpA/ClpB family. | 0.425 |
Bcav_3706 | Bcav_3707 | Bcav_3706 | Bcav_3707 | PFAM: MerR family regulatory protein. | PFAM: DnaJ C terminal region; DnaJ domain. | 0.954 |
Bcav_3706 | clpB | Bcav_3706 | Bcav_3653 | PFAM: MerR family regulatory protein. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.425 |