node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Jden_0898 | prcA | Jden_0898 | Jden_1205 | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.650 |
Jden_0898 | prcB | Jden_0898 | Jden_1204 | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.703 |
Jden_1202 | Jden_1203 | Jden_1202 | Jden_1203 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.952 |
Jden_1202 | Jden_1207 | Jden_1202 | Jden_1207 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | PFAM: peptidylprolyl isomerase FKBP-type; KEGG: gbm:Gbem_1109 peptidylprolyl isomerase FKBP- type. | 0.510 |
Jden_1202 | arc | Jden_1202 | Jden_1201 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.974 |
Jden_1202 | hisF | Jden_1202 | Jden_1208 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.506 |
Jden_1202 | pafA | Jden_1202 | Jden_1206 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.768 |
Jden_1202 | prcA | Jden_1202 | Jden_1205 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.954 |
Jden_1202 | prcB | Jden_1202 | Jden_1204 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.950 |
Jden_1203 | Jden_1202 | Jden_1203 | Jden_1202 | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | 0.952 |
Jden_1203 | Jden_1207 | Jden_1203 | Jden_1207 | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | PFAM: peptidylprolyl isomerase FKBP-type; KEGG: gbm:Gbem_1109 peptidylprolyl isomerase FKBP- type. | 0.659 |
Jden_1203 | Jden_2253 | Jden_1203 | Jden_2253 | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | KEGG: cell division cycle protein 48; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; Belongs to the AAA ATPase family. | 0.759 |
Jden_1203 | arc | Jden_1203 | Jden_1201 | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.999 |
Jden_1203 | hisF | Jden_1203 | Jden_1208 | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.648 |
Jden_1203 | pafA | Jden_1203 | Jden_1206 | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.970 |
Jden_1203 | prcA | Jden_1203 | Jden_1205 | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.992 |
Jden_1203 | prcB | Jden_1203 | Jden_1204 | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.993 |
Jden_1207 | Jden_1202 | Jden_1207 | Jden_1202 | PFAM: peptidylprolyl isomerase FKBP-type; KEGG: gbm:Gbem_1109 peptidylprolyl isomerase FKBP- type. | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | 0.510 |
Jden_1207 | Jden_1203 | Jden_1207 | Jden_1203 | PFAM: peptidylprolyl isomerase FKBP-type; KEGG: gbm:Gbem_1109 peptidylprolyl isomerase FKBP- type. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.659 |
Jden_1207 | arc | Jden_1207 | Jden_1201 | PFAM: peptidylprolyl isomerase FKBP-type; KEGG: gbm:Gbem_1109 peptidylprolyl isomerase FKBP- type. | AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.523 |