node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACU95248.1 | arc | Svir_01600 | Svir_22080 | PFAM: Protein of unknown function (DUF2587). | ATP-dependent 26S proteasome regulatory subunit; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.804 |
ACU95248.1 | pafA | Svir_01600 | Svir_21990 | PFAM: Protein of unknown function (DUF2587). | Putative proteasome component/protein of unknown function, DUF275; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.722 |
ACU95248.1 | prcA | Svir_01600 | Svir_22020 | PFAM: Protein of unknown function (DUF2587). | 20S proteasome subunit (alpha or beta); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.994 |
ACU95248.1 | prcB | Svir_01600 | Svir_22030 | PFAM: Protein of unknown function (DUF2587). | Proteasome endopeptidase complex, beta component; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.958 |
ACU95248.1 | pup | Svir_01600 | Svir_22040 | PFAM: Protein of unknown function (DUF2587). | Protein of unknown function (DUF797); Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.688 |
ACU97205.1 | ACU97206.1 | Svir_21970 | Svir_21980 | Predicted transcriptional regulator. | Predicted transcriptional regulator. | 0.996 |
ACU97205.1 | ACU97208.1 | Svir_21970 | Svir_22000 | Predicted transcriptional regulator. | Sphingosine/diacylglycerol kinase-like enzyme; PFAM: Diacylglycerol kinase catalytic domain; PAP2 superfamily. | 0.419 |
ACU97205.1 | pafA | Svir_21970 | Svir_21990 | Predicted transcriptional regulator. | Putative proteasome component/protein of unknown function, DUF275; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.782 |
ACU97205.1 | prcA | Svir_21970 | Svir_22020 | Predicted transcriptional regulator. | 20S proteasome subunit (alpha or beta); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.474 |
ACU97205.1 | tatA | Svir_21970 | Svir_21960 | Predicted transcriptional regulator. | Twin arginine-targeting protein translocase, TatA/E family; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.511 |
ACU97206.1 | ACU97205.1 | Svir_21980 | Svir_21970 | Predicted transcriptional regulator. | Predicted transcriptional regulator. | 0.996 |
ACU97206.1 | ACU97208.1 | Svir_21980 | Svir_22000 | Predicted transcriptional regulator. | Sphingosine/diacylglycerol kinase-like enzyme; PFAM: Diacylglycerol kinase catalytic domain; PAP2 superfamily. | 0.419 |
ACU97206.1 | pafA | Svir_21980 | Svir_21990 | Predicted transcriptional regulator. | Putative proteasome component/protein of unknown function, DUF275; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.782 |
ACU97206.1 | prcA | Svir_21980 | Svir_22020 | Predicted transcriptional regulator. | 20S proteasome subunit (alpha or beta); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.552 |
ACU97206.1 | tatA | Svir_21980 | Svir_21960 | Predicted transcriptional regulator. | Twin arginine-targeting protein translocase, TatA/E family; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.602 |
ACU97208.1 | ACU97205.1 | Svir_22000 | Svir_21970 | Sphingosine/diacylglycerol kinase-like enzyme; PFAM: Diacylglycerol kinase catalytic domain; PAP2 superfamily. | Predicted transcriptional regulator. | 0.419 |
ACU97208.1 | ACU97206.1 | Svir_22000 | Svir_21980 | Sphingosine/diacylglycerol kinase-like enzyme; PFAM: Diacylglycerol kinase catalytic domain; PAP2 superfamily. | Predicted transcriptional regulator. | 0.419 |
ACU97208.1 | pafA | Svir_22000 | Svir_21990 | Sphingosine/diacylglycerol kinase-like enzyme; PFAM: Diacylglycerol kinase catalytic domain; PAP2 superfamily. | Putative proteasome component/protein of unknown function, DUF275; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.574 |
arc | ACU95248.1 | Svir_22080 | Svir_01600 | ATP-dependent 26S proteasome regulatory subunit; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | PFAM: Protein of unknown function (DUF2587). | 0.804 |
arc | pafA | Svir_22080 | Svir_21990 | ATP-dependent 26S proteasome regulatory subunit; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | Putative proteasome component/protein of unknown function, DUF275; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.961 |