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pafA protein (Saccharomonospora viridis) - STRING interaction network
"pafA" - Pup--protein ligase in Saccharomonospora viridis
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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pafAPup--protein ligase; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (452 aa)    
Predicted Functional Partners:
arc
Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a ’key in a lock’ to induce gate opening and therefore regulate proteolysis (602 aa)
 
 
  0.963
prcA
Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation; Belongs to the peptidase T1A family (255 aa)
     
  0.950
prcB
Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation; Belongs to the peptidase T1B family (289 aa)
 
   
  0.881
Svir_21980
annotation not available (327 aa)
   
   
  0.876
Svir_21970
annotation not available (326 aa)
   
   
  0.873
pup
Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation; Belongs to the prokaryotic ubiquitin-like protein family (63 aa)
 
     
  0.858
Svir_34520
PFAM- ATPase family associated with various cellular activities (AAA); ATPase family associated with various cellular activities (AAA); Belongs to the AAA ATPase family (747 aa)
   
 
  0.774
Svir_01600
PFAM- Protein of unknown function (DUF2587) (183 aa)
   
 
  0.770
Svir_22000
Sphingosine/diacylglycerol kinase-like enzyme; PFAM- Diacylglycerol kinase catalytic domain; PAP2 superfamily (480 aa)
              0.715
Svir_10320
annotation not available (138 aa)
   
          0.629
Your Current Organism:
Saccharomonospora viridis
NCBI taxonomy Id: 471857
Other names: S. viridis DSM 43017, Saccharomonospora viridis, Saccharomonospora viridis ATCC 15386, Saccharomonospora viridis DSM 43017, Saccharomonospora viridis DSM43017, Saccharomonospora viridis NCIB 9602, Saccharomonospora viridis NRRL B-3044, Saccharomonospora viridis str. DSM 43017, Saccharomonospora viridis strain DSM 43017
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