Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated (359 aa)
Predicted Functional Partners:
Serine/threonine-protein phosphatase (311 aa)
Serine/threonine-protein phosphatase (319 aa)
Succinyl CoA transferase, putative; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (497 aa)
Succinyl-CoA-3-ketoacid-coenzyme A transferase subunit A (401 aa)