node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Namu_0288 | Namu_2971 | Namu_0288 | Namu_2971 | Hypothetical protein. | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | 0.700 |
Namu_0288 | arc | Namu_0288 | Namu_2975 | Hypothetical protein. | AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.824 |
Namu_0288 | pafA | Namu_0288 | Namu_2960 | Hypothetical protein. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.732 |
Namu_0288 | prcA | Namu_0288 | Namu_2968 | Hypothetical protein. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.990 |
Namu_0288 | prcB | Namu_0288 | Namu_2969 | Hypothetical protein. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.935 |
Namu_0288 | pup | Namu_0288 | Namu_2970 | Hypothetical protein. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.730 |
Namu_1696 | Namu_3313 | Namu_1696 | Namu_3313 | PFAM: Mov34/MPN/PAD-1 family protein; SMART: Mov34/MPN/PAD-1 family protein; KEGG: nmu:Nmul_A0971 Mov34/MPN/PAD-1. | PFAM: carbohydrate kinase FGGY; KEGG: xac:XAC0358 glycerol kinase; Belongs to the FGGY kinase family. | 0.748 |
Namu_1696 | arc | Namu_1696 | Namu_2975 | PFAM: Mov34/MPN/PAD-1 family protein; SMART: Mov34/MPN/PAD-1 family protein; KEGG: nmu:Nmul_A0971 Mov34/MPN/PAD-1. | AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.977 |
Namu_1696 | glpK | Namu_1696 | Namu_1531 | PFAM: Mov34/MPN/PAD-1 family protein; SMART: Mov34/MPN/PAD-1 family protein; KEGG: nmu:Nmul_A0971 Mov34/MPN/PAD-1. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.748 |
Namu_1696 | prcA | Namu_1696 | Namu_2968 | PFAM: Mov34/MPN/PAD-1 family protein; SMART: Mov34/MPN/PAD-1 family protein; KEGG: nmu:Nmul_A0971 Mov34/MPN/PAD-1. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.866 |
Namu_1696 | prcB | Namu_1696 | Namu_2969 | PFAM: Mov34/MPN/PAD-1 family protein; SMART: Mov34/MPN/PAD-1 family protein; KEGG: nmu:Nmul_A0971 Mov34/MPN/PAD-1. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.866 |
Namu_2971 | Namu_0288 | Namu_2971 | Namu_0288 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | Hypothetical protein. | 0.700 |
Namu_2971 | arc | Namu_2971 | Namu_2975 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.897 |
Namu_2971 | prcA | Namu_2971 | Namu_2968 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.929 |
Namu_2971 | prcB | Namu_2971 | Namu_2969 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.943 |
Namu_2971 | pup | Namu_2971 | Namu_2970 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.946 |
Namu_3313 | Namu_1696 | Namu_3313 | Namu_1696 | PFAM: carbohydrate kinase FGGY; KEGG: xac:XAC0358 glycerol kinase; Belongs to the FGGY kinase family. | PFAM: Mov34/MPN/PAD-1 family protein; SMART: Mov34/MPN/PAD-1 family protein; KEGG: nmu:Nmul_A0971 Mov34/MPN/PAD-1. | 0.748 |
Namu_3313 | arc | Namu_3313 | Namu_2975 | PFAM: carbohydrate kinase FGGY; KEGG: xac:XAC0358 glycerol kinase; Belongs to the FGGY kinase family. | AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.761 |
Namu_3313 | prcA | Namu_3313 | Namu_2968 | PFAM: carbohydrate kinase FGGY; KEGG: xac:XAC0358 glycerol kinase; Belongs to the FGGY kinase family. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.657 |
Namu_3313 | prcB | Namu_3313 | Namu_2969 | PFAM: carbohydrate kinase FGGY; KEGG: xac:XAC0358 glycerol kinase; Belongs to the FGGY kinase family. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.657 |