STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Caci_7799PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein; KEGG: sma:SAV_3072 ATP-dependent DNA helicase. (787 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
 0.996
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.994
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.992
Caci_2443
PFAM: 5'-3' exonuclease; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; KEGG: sgr:SGR_5889 putative 5'-3' exonuclease.
 
 0.987
Caci_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 0.986
Caci_1413
KEGG: nca:Noca_2281 hypothetical protein.
  
 0.976
Caci_7807
PFAM: UvrD/REP helicase; KEGG: sgr:SGR_2341 putative ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily.
 
0.973
Caci_7996
TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; KEGG: sco:SCO4797 ATP-dependent DNA helicase II.
 
0.973
Caci_0415
PFAM: SNF2-related protein; helicase domain protein; SMART: DEAD-like helicases; helicase domain protein; KEGG: sgr:SGR_1018 hypothetical protein.
  
 
 0.970
Caci_2463
PFAM: metallophosphoesterase; KEGG: mkm:Mkms_4009 metallophosphoesterase.
  
 0.969
Your Current Organism:
Catenulispora acidiphila
NCBI taxonomy Id: 479433
Other names: C. acidiphila DSM 44928, Catenulispora acidiphila DSM 44928, Catenulispora acidiphila str. DSM 44928, Catenulispora acidiphila strain DSM 44928
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