STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Elen_1951TIGRFAM: DNA ligase D; DNA polymerase LigD, ligase domain protein; DNA polymerase LigD, polymerase domain protein; DNA ligase D, 3'-phosphoesterase domain protein; PFAM: ATP dependent DNA ligase; DNA primase small subunit; ATP dependent DNA ligase domain protein; KEGG: sme:SMc03959 hypothetical protein. (822 aa)    
Predicted Functional Partners:
Elen_0003
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.980
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.974
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.972
Elen_0120
Exodeoxyribonuclease III Xth; KEGG: hhe:HH0928 exodeoxyribonuclease LexA; TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase.
  
 
 0.893
Elen_1633
PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease; KEGG: mex:Mext_0325 exonuclease RNase T and DNA polymerase III.
  
  
 0.804
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.702
Elen_0799
PFAM: helicase domain protein; type III restriction protein res subunit; SMART: DEAD-like helicase; helicase domain protein; KEGG: bbr:BB0908 putative helicase.
  
 0.701
Elen_2721
KEGG: bce:BC4403 single-stranded-DNA-specific exonuclease RecJ; TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase RecJ domain protein; helicase domain protein; DEAD/DEAH box helicase domain protein; phosphoesterase DHHA1; SMART: helicase domain protein; DEAD-like helicase.
  
 
 0.662
Elen_2188
PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: pag:PLES_31851 putative short-chain dehydrogenase.
 
   
 0.647
Elen_0027
PFAM: metallophosphoesterase; KEGG: scl:sce7166 DNA repair exonuclease family protein.
  
 0.644
Your Current Organism:
Eggerthella lenta
NCBI taxonomy Id: 479437
Other names: E. lenta DSM 2243, Eggerthella lenta DSM 2243, Eggerthella lenta str. DSM 2243, Eggerthella lenta strain DSM 2243
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.