node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cbpA | clpA | Minf_0945 | Minf_0106 | DnaJ-class molecular chaperone. | ATP-binding subunits of Clp protease ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.622 |
cbpA | clpA-2 | Minf_0945 | Minf_0241 | DnaJ-class molecular chaperone. | ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones; Belongs to the ClpA/ClpB family. | 0.622 |
cbpA | clpP | Minf_0945 | Minf_1039 | DnaJ-class molecular chaperone. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.463 |
cbpA | dnaK | Minf_0945 | Minf_2178 | DnaJ-class molecular chaperone. | Chaperone DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.997 |
cbpA | glyA | Minf_0945 | Minf_1669 | DnaJ-class molecular chaperone. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | 0.442 |
cbpA | groL | Minf_0945 | Minf_2176 | DnaJ-class molecular chaperone. | Chaperonin GroEL (HSP60 family); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.776 |
cbpA | groS | Minf_0945 | Minf_2177 | DnaJ-class molecular chaperone. | Co-chaperonin GroES (HSP10); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.637 |
cbpA | grpE | Minf_0945 | Minf_2254 | DnaJ-class molecular chaperone. | Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...] | 0.933 |
clpA | cbpA | Minf_0106 | Minf_0945 | ATP-binding subunits of Clp protease ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | DnaJ-class molecular chaperone. | 0.622 |
clpA | clpP | Minf_0106 | Minf_1039 | ATP-binding subunits of Clp protease ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.918 |
clpA | dnaJ | Minf_0106 | Minf_2253 | ATP-binding subunits of Clp protease ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | DnaJ-class molecular chaperone with C-terminal Zn finger domain; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of A [...] | 0.622 |
clpA | dnaK | Minf_0106 | Minf_2178 | ATP-binding subunits of Clp protease ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.946 |
clpA | glyA | Minf_0106 | Minf_1669 | ATP-binding subunits of Clp protease ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | 0.509 |
clpA | groL | Minf_0106 | Minf_2176 | ATP-binding subunits of Clp protease ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperonin GroEL (HSP60 family); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.553 |
clpA | groS | Minf_0106 | Minf_2177 | ATP-binding subunits of Clp protease ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Co-chaperonin GroES (HSP10); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.615 |
clpA | grpE | Minf_0106 | Minf_2254 | ATP-binding subunits of Clp protease ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...] | 0.769 |
clpA-2 | cbpA | Minf_0241 | Minf_0945 | ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones; Belongs to the ClpA/ClpB family. | DnaJ-class molecular chaperone. | 0.622 |
clpA-2 | clpP | Minf_0241 | Minf_1039 | ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.929 |
clpA-2 | dnaJ | Minf_0241 | Minf_2253 | ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones; Belongs to the ClpA/ClpB family. | DnaJ-class molecular chaperone with C-terminal Zn finger domain; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of A [...] | 0.622 |
clpA-2 | dnaK | Minf_0241 | Minf_2178 | ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones; Belongs to the ClpA/ClpB family. | Chaperone DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.958 |