STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
pyrE_1Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (175 aa)    
Predicted Functional Partners:
preA
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA.
  
 0.939
pyrF
Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily.
 
 
 0.937
guaA_2
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.896
pyrR
Bifunctional protein PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
  
 
 0.879
pyrD
Dihydroorotate dehydrogenase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate.
 
 0.861
thrZ
threonine--tRNA ligase 2.
  
 0.843
pyrB
Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
  
 0.837
carB_2
Carbamoyl-phosphate synthase large chain; Belongs to the CarB family.
 
 
 0.835
uraA
Uracil permease.
  
  
 0.811
pyrK_1
Dihydroorotate dehydrogenase B, electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
  
 
 0.809
Your Current Organism:
Ruminiclostridium hungatei
NCBI taxonomy Id: 48256
Other names: ATCC 700212, Clostridium hungatei, Clostridium hungatei Monserrate et al. 2001, DSM 14427, R. hungatei, strain AD
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