node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
THA_1094 | THA_1732 | THA_1094 | THA_1732 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Methenyltetrahydrofolate cyclohydrolase. | 0.553 |
THA_1094 | THA_738 | THA_1094 | THA_738 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Bifunctional purine biosynthesis protein PurH. | 0.910 |
THA_1094 | fhs | THA_1094 | THA_555 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Fhs formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.965 |
THA_1094 | folA | THA_1094 | THA_624 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Dihydrofolate reductase. | 0.939 |
THA_1094 | folD | THA_1094 | THA_201 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.660 |
THA_1094 | ftcD | THA_1094 | THA_1560 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Glutamate formiminotransferase. | 0.900 |
THA_1094 | gcvT | THA_1094 | THA_181 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.967 |
THA_1094 | glyA | THA_1094 | THA_1054 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.950 |
THA_1094 | purN | THA_1094 | THA_737 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.920 |
THA_1094 | thyX | THA_1094 | THA_203 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.920 |
THA_1732 | THA_1094 | THA_1732 | THA_1094 | Methenyltetrahydrofolate cyclohydrolase. | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | 0.553 |
THA_1732 | THA_738 | THA_1732 | THA_738 | Methenyltetrahydrofolate cyclohydrolase. | Bifunctional purine biosynthesis protein PurH. | 0.903 |
THA_1732 | fhs | THA_1732 | THA_555 | Methenyltetrahydrofolate cyclohydrolase. | Fhs formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.949 |
THA_1732 | folD | THA_1732 | THA_201 | Methenyltetrahydrofolate cyclohydrolase. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.943 |
THA_1732 | ftcD | THA_1732 | THA_1560 | Methenyltetrahydrofolate cyclohydrolase. | Glutamate formiminotransferase. | 0.998 |
THA_1732 | gcvT | THA_1732 | THA_181 | Methenyltetrahydrofolate cyclohydrolase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.934 |
THA_1732 | purN | THA_1732 | THA_737 | Methenyltetrahydrofolate cyclohydrolase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.910 |
THA_738 | THA_1094 | THA_738 | THA_1094 | Bifunctional purine biosynthesis protein PurH. | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | 0.910 |
THA_738 | THA_1732 | THA_738 | THA_1732 | Bifunctional purine biosynthesis protein PurH. | Methenyltetrahydrofolate cyclohydrolase. | 0.903 |
THA_738 | fhs | THA_738 | THA_555 | Bifunctional purine biosynthesis protein PurH. | Fhs formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.976 |