node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Phep_0646 | Phep_1041 | Phep_0646 | Phep_1041 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | 0.900 |
Phep_0646 | Phep_2180 | Phep_0646 | Phep_2180 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | PFAM: Phosphorylase superfamily. | 0.916 |
Phep_0646 | Phep_2185 | Phep_0646 | Phep_2185 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; Belongs to the 5'-nucleotidase family. | 0.913 |
Phep_0646 | Phep_3862 | Phep_0646 | Phep_3862 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | PFAM: 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C). | 0.900 |
Phep_0646 | surE | Phep_0646 | Phep_3500 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.903 |
Phep_0646 | surE-2 | Phep_0646 | Phep_3515 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.903 |
Phep_0646 | tdk | Phep_0646 | Phep_0802 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | PFAM: Thymidine kinase. | 0.917 |
Phep_0992 | Phep_2185 | Phep_0992 | Phep_2185 | PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; Belongs to the 5'-nucleotidase family. | 0.904 |
Phep_0992 | Phep_3862 | Phep_0992 | Phep_3862 | PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | PFAM: 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C). | 0.901 |
Phep_0992 | dut | Phep_0992 | Phep_3841 | PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.938 |
Phep_0992 | surE | Phep_0992 | Phep_3500 | PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
Phep_0992 | surE-2 | Phep_0992 | Phep_3515 | PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
Phep_0992 | tdk | Phep_0992 | Phep_0802 | PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | PFAM: Thymidine kinase. | 0.929 |
Phep_0992 | thyA | Phep_0992 | Phep_1422 | PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.932 |
Phep_1041 | Phep_0646 | Phep_1041 | Phep_0646 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.900 |
Phep_1041 | Phep_2180 | Phep_1041 | Phep_2180 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | PFAM: Phosphorylase superfamily. | 0.908 |
Phep_1041 | Phep_2185 | Phep_1041 | Phep_2185 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; Belongs to the 5'-nucleotidase family. | 0.900 |
Phep_1041 | Phep_3862 | Phep_1041 | Phep_3862 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | PFAM: 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C). | 0.900 |
Phep_1041 | surE | Phep_1041 | Phep_3500 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
Phep_1041 | surE-2 | Phep_1041 | Phep_3515 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |