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rad50 protein (Schizosaccharomyces pombe) - STRING interaction network
"rad50" - DNA repair protein Rad50 in Schizosaccharomyces pombe
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second shell of interactors
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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rad50DNA repair protein Rad50; Involved in DNA double-strand break (DSB) repair. Involved in mating type switching and has a role in choosing the sister chromatid for recombinational repair. Also has a role in telomere length maintenance (1285 aa)    
Predicted Functional Partners:
rad32
Mre11 nuclease; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51 (649 aa)
   
  0.999
tel1
ATM checkpoint kinase; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Undirectly involved in the phosphorylation of rad32 which is necessary for its telomere function. Required for the control of telomere length and genome stability (2812 aa)
     
  0.998
nbs1
Mre11 complex subunit Nbs1; Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure (613 aa)
     
 
  0.988
psm3
Mitotic cohesin complex subunit Psm3; Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (1194 aa)
   
  0.985
rad3
ATR checkpoint kinase Rad3; Serine/threonine kinase which activates checkpoint signaling upon genotoxic stresses. Involved in G2 arrest following DNA damage where it phosphorylates chk1 (PubMed-8978690, PubMed-1398093). Phosphorylation of ’Thr-73’ and ’Ser-80’ of checkpoint mediator crb2 promotes its interaction with chk1 (PubMed-14739927). It is also involved in the dependence of mitosis on the completion of DNA replication (PubMed-1398093) (2386 aa)
     
 
  0.981
rhp51
RecA family recombinase Rad51/Rhp51; Required both for recombination and for the repair of DNA damage caused by X-rays. Binds to single and double-stranded DNA, in the presence of magnesium, and exhibits DNA-dependent ATPase activity. Promotes DNA strand annealing and strand exchange via DNA recombinase activity and forms helical nucleoprotein filaments (365 aa)
   
 
  0.981
pku70
Ku domain protein Pku70; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Required for mati [...] (607 aa)
     
 
  0.980
pku80
Ku domain protein Pku80; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telom [...] (695 aa)
     
 
  0.976
rhp55
RecA family ATPase Rad55/Rhp55; Required for radiation resistance and meiotic viability and acts in recombination and recombinational DNA repair pathways (350 aa)
   
 
  0.971
exo1
Exonuclease I Exo1; 5’->3’ double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs (571 aa)
     
 
  0.962
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 4896
Other names: S. pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombe, fission yeast
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