SPAC167.07c.1 protein (Schizosaccharomyces pombe) - STRING interaction network
"SPAC167.07c.1" - Probable E3 ubiquitin protein ligase C167.07c in Schizosaccharomyces pombe
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Known Interactions
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Predicted Interactions
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Gene Fusion
SPAC167.07c.1Probable E3 ubiquitin protein ligase C167.07c; Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (1029 aa)    
Predicted Functional Partners:
UBR ubiquitin ligase Ubr11; Belongs to the UBR1 family (2052 aa)
E3 ubiquitin-protein ligase ubr1; Ubiquitin ligase protein which is a component of the N- end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation; Belongs to the UBR1 family (1958 aa)
Probable ubiquitin fusion degradation protein C12B10.01c; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (1647 aa)
Ubiquitin-conjugating enzyme E2 1; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (217 aa)
Ubiquitin-conjugating enzyme E2 15; Catalyzes the covalent attachment of ubiquitin to other proteins. Has a role in the formation of chromatin structures that influence the localization of transcriptional silencing factors (167 aa)
E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to cdc48 recruitment for extraction and degradation of the incomplete translation product (1610 aa)
Ubiquitin carboxyl-terminal hydrolase 6; Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin; Belongs to the peptidase C19 family. USP14/UBP6 subfamily (468 aa)
Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Component of the histone H2B ubiquitin ligase complex (HULC) which plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation (By similarity). Required for obr1 ubiquitination, whi [...] (151 aa)
Ubiquitin-conjugating enzyme E2 4; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Mediates ubiquitination of PEX5 (147 aa)
Ubiquitin conjugation factor E4; E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly. Binds to cdc48 and elongates mono- and diubiquitinated ERAD substrates presented by the ufd1-npl4-cdc48 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties. Delivers these polyubiquitinated substrates to downstream ERAD components, which target them to the proteasome. Enhances ubiquitination at ’Lys-48’, but not at ’Lys- 29’ of the Ub moiety (1010 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 4896
Other names: CBS 356, CCRC 21461, DBVPG 6277, JCM 8274, MUCL 30245, NRRL Y-12796, S. pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombe, fission yeast
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