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gsk3 protein (Schizosaccharomyces pombe) - STRING interaction network
"gsk3" - Protein kinase gsk3 in Schizosaccharomyces pombe
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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gsk3Protein kinase gsk3; Interacts with cdc14 which is thought to play a role in the initiation and completion of mitosis. Involved in the positive regulation of mis12; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily (387 aa)    
Predicted Functional Partners:
hsf1
Heat shock factor protein; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. Also required for growth at normal temperatures (609 aa)
     
  0.948
rgs1
Regulator of G-protein signaling 1; Negatively regulates pheromone signaling during mating. Acts in a negative feedback loop that is essential for the mating process. This loop acts to down-regulate cellular sensitivity to pheromone. Activated by ste11 (481 aa)
     
 
  0.931
pof11
F-box/WD repeat-containing protein pof11; Has a role in meiosis (506 aa)
       
 
  0.919
hsp90
Heat shock protein 90 homolog; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). Interacts with the wee1 protein kinase; which req [...] (704 aa)
       
 
  0.802
ppe1
Serine/threonine-protein phosphatase ppe1; Has a role in chromosome segregation. May provide a dynamic connection between kinetochore microtubules and kinetochore chromatin. Negatively regulates mis12; Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily (305 aa)
   
 
  0.792
hhp1
Casein kinase I homolog hhp1; Involved in DNA repair. Has a probable role in repairing alkylated DNA and may regulate the activity of protein(s) involved in double strand break repair caused by gamma rays (365 aa)
   
 
  0.785
ptn1
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase ptn1; Acts as a phosphoinositide 3-phosphatase and regulates PtdIns(3,4,5)P3 levels (348 aa)
     
 
  0.761
tsc2
Tuberous sclerosis 2 protein homolog; Together with tsc1, required for uptake of various amino acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1 (1339 aa)
       
 
  0.754
ins1
INSIG domain protein (281 aa)
     
   
  0.732
cdc14
Cell division control protein 14; Has a role in the septation initiation network (SIN) required for cytokinesis (240 aa)
       
      0.708
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 4896
Other names: CBS 356, CCRC 21461, DBVPG 6277, JCM 8274, MUCL 30245, NRRL Y-12796, S. pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombe, fission yeast
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