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tup11 protein (Schizosaccharomyces pombe) - STRING interaction network
"tup11" - Transcriptional repressor tup11 in Schizosaccharomyces pombe
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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tup11Transcriptional repressor tup11; Transcriptional repressor (614 aa)    
Predicted Functional Partners:
ssn6
General transcriptional corepressor ssn6; Acts as component of the ssn6-tup corepressor complexes, which are involved in the repression of many genes in a wide variety of physiological processes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone dea [...] (1102 aa)
     
  0.999
atf1
Transcription factor atf1; Transcription factor required for sexual development and entry into stationary phase. Binds and activates meiotic recombination hot spot ade6-M26; Belongs to the bZIP family (566 aa)
       
  0.982
fep1
Iron-sensing transcription factor 1; Represses the expression of the iron transporter fio1 in response to high iron concentrations. Binds to the consensus sequence 5’-[AT]GATAA-3’. Also represses the expression of str1, str2 and str3 (564 aa)
       
 
  0.933
set1
Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the Set1 complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Methylation promotes maintenance of active chromatin states at euchromatic chromosomal domains and is present throughout the cell cycle. Plays a role in telomere maintenance and DNA repair in an ATM kinase rad3-dependent pathway. Required for efficient telomeric and centromeric silencing; Belongs to the class V-like SAM-binding methyltransferase superfamily (920 aa)
     
 
  0.914
pcr1
Transcription factor pcr1; Involved in regulation of gene expression for sexual development. Binds and activates meiotic recombination hot spot ade6-M26 (171 aa)
       
  0.909
lkh1
Dual specificity protein kinase lkh1; Protein kinase that may act as a negative regulator of filamentous growth and flocculation. Appears to have a role in normal cell wall and septum formation and in cell separation. May have antagonistic function in the regulation of beta-glucan distribution between the sites for cell wall and septum assembly; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily (690 aa)
     
 
  0.890
ash2
Set1 complex component ash2; The Set1 complex specifically methylates ’Lys-4’ of histone H3 (652 aa)
     
 
  0.882
scr1
DNA-binding protein scr1; Involved in carbon catabolite repression. Represses the transcription of various genes including the inv1 gene (565 aa)
       
 
  0.865
clr3
Histone deacetylase clr3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac- containing repressor complex (SHREC) (687 aa)
     
  0.860
tup12
Transcriptional repressor tup12; Transcriptional repressor (598 aa)
   
 
0.831
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 4896
Other names: CBS 356, CCRC 21461, DBVPG 6277, JCM 8274, MUCL 30245, NRRL Y-12796, S. pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombe, fission yeast
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