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dcp2 protein (Schizosaccharomyces pombe) - STRING interaction network
"dcp2" - mRNA decapping complex subunit 2 in Schizosaccharomyces pombe
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Predicted Interactions
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dcp2mRNA decapping complex subunit 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5’ to 3’ exonucleolytic decay of the transcript body (741 aa)    
Predicted Functional Partners:
dcp1
mRNA-decapping enzyme subunit 1; Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5’ to 3’ exonucleolytic decay of the transcript body; Belongs to the DCP1 family (127 aa)
     
  0.999
edc3
Enhancer of mRNA-decapping protein 3; Stimulates decapping of both stable and unstable mRNA during mRNA decay. Stimulates decapping presumably by preventing the DCP1-DCP2 decapping complex from adopting an inactive conformation; Belongs to the EDC3 family (454 aa)
       
 
  0.999
exo2
5’-3’ exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5’-3’ exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. Involved in the degradation of several hypomodified mature tRNA species and participates in the 5’-processing or the degradation of the snoRNA pr [...] (1328 aa)
     
  0.999
lsm1
U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. The LSM1-LSM7 complex binds RNA with a preference for poly-U ends (140 aa)
       
  0.996
sum2
Protein sum2; Required for G2/M phase checkpoint control (426 aa)
     
 
  0.992
ste13
Putative ATP-dependent RNA helicase ste13; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA- damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily (485 aa)
     
 
  0.991
SPBC19G7.10c.1
DNA topoisomerase 2-associated protein pat1; Activator of decapping that functions as a general and active mechanism of translational repression and required for P- body formation. Stabilizes the 3’ terminus of mRNAs and modulates the rates of mRNA-decapping that occur following deadenylation. Might be required for promoting the formation or the stabilization of the preinitiation translation complexes. Necessary for accurate chromosome transmission during cell division (By similarity) (754 aa)
     
 
  0.988
upf1
ATP-dependent helicase upf1; Required for rapid turnover of mRNAs containing a premature translational termination codon (925 aa)
     
 
  0.970
dis3
Exosome complex exonuclease dis3; Catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] (970 aa)
   
  0.969
lsm4
Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3’-terminal U-tract of U6 snRNA (121 aa)
     
 
  0.967
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 4896
Other names: CBS 356, CCRC 21461, DBVPG 6277, JCM 8274, MUCL 30245, NRRL Y-12796, S. pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombe, fission yeast
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