STRINGSTRING
SPAC1D4.01 protein (Schizosaccharomyces pombe) - STRING interaction network
"SPAC1D4.01" - Telomere length and silencing protein 1 in Schizosaccharomyces pombe
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPAC1D4.01Telomere length and silencing protein 1; Involved in the regulation of heterochromatin assembly at telomeric regions. Involved in the control of telomere length. Regulates spliceosome assembly by associating with brr2. Regulates the proper splicing of mRNAs of the shelterin components rap1 and poz1 to control telomeric heterochromatin assembly and telomere length (254 aa)    
Predicted Functional Partners:
cwf14
Pre-mRNA-splicing factor cwf14; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome (146 aa)
           
  0.752
brr2
Pre-mRNA-splicing factor brr2; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3’ splice site selection. Associates with the branch site-3’ splice 3’-exon region (2176 aa)
           
  0.707
SPBC582.04c.1
Uncharacterized protein C582.04c; RNAi protein, Dsh1 (583 aa)
     
   
  0.653
meu6
Meiotic chromosome segregation protein Meu6 (651 aa)
           
  0.650
vps1302
Vacuolar protein sorting-associated protein 13b; May be involved in recycling of membrane proteins between an endocytic compartment and the TGN (3004 aa)
           
  0.602
tlh1
RecQ type DNA helicase (1887 aa)
           
  0.573
arb2
Argonaute-binding protein 2; A member of the argonaute siRNA chaperone (ARC) complex which is required for histone H3K9 methylation, heterochromatin assembly and siRNA generation. The ARC complex contains mostly double-stranded siRNA. Inhibits the release of the siRNA passenger strand from ago1 together with arb1 (321 aa)
     
   
  0.565
vps13a
Vacuolar protein sorting-associated protein 13a; May be involved in recycling of membrane proteins between an endocytic compartment and the TGN (3071 aa)
           
  0.560
pcp1
Spindle pole body protein pcp1; Spindle pole body component that binds calmodulin. Overexpression of pcp1 causes the formation of supernumerary SPB- like structures and disrupts both mitotic spindle assembly and chromosome segregation (1208 aa)
     
        0.491
vps10
Vacuolar protein sorting/targeting protein 10; Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (1466 aa)
           
  0.450
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 4896
Other names: CBS 356, CCRC 21461, DBVPG 6277, JCM 8274, MUCL 30245, NRRL Y-12796, S. pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombe, fission yeast
Server load: low (9%) [HD]