STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPAC222.13c.1Probable 6-phosphofructo-2-kinase C222.13c; Synthesis of fructose 2,6-bisphosphate (592 aa)    
Predicted Functional Partners:
fbp1
Fructose-1,6-bisphosphatase Fbp1
   
 
 0.962
pfk1
ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. May also have a role in cell cycle regulation
   
 0.962
hxk1
Hexokinase-1; Has low affinity for glucose and some of its analogs; Belongs to the hexokinase family
   
 0.926
hxk2
Hexokinase-2; Hexokinase 2
   
 0.926
SPBC2G2.16
Mannose-6-phosphate isomerase; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions
   
 0.920
pka1
cAMP-dependent protein kinase catalytic subunit Pka1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily
   
 
 0.816
SPAPB17E12.14c.1
Probable 6-phosphofructo-2-kinase PB17E12.14c; Synthesis of fructose 2,6-bisphosphate
  
 
 
0.812
SPCC16C4.10.1
Probable 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate
  
  
 0.744
SPAC1B1.02c.1
Uncharacterized kinase C1B1.02c; NAD/NADH kinase (predicted); Belongs to the NAD kinase family
  
  
 0.722
SPBC1773.04.1
Putative uncharacterized oxidoreductase C1773.04; Methylglyoxyl reductase (NADPH-dependent) (predicted); Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily
      
 0.615
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 4896
Other names: CBS 356, CCRC 21461, DBVPG 6277, JCM 8274, MUCL 30245, NRRL Y-12796, S. pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombe, fission yeast
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