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abc3 protein (Schizosaccharomyces pombe) - STRING interaction network
"abc3" - ATP-binding cassette transporter abc3 in Schizosaccharomyces pombe
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
abc3ATP-binding cassette transporter abc3; Iron-regulated vacuolar ABC-type transporter which may be responsible for mobilizing stored iron from the vacuole to the cytosol in response to iron deficiency (1465 aa)    
Predicted Functional Partners:
fip1
Plasma membrane iron permease; Permease for high affinity iron uptake (397 aa)
     
 
  0.950
str3
Siderophore iron transporter 3; Involved in the transport of siderophore iron and so has a role in iron homeostasis (630 aa)
     
   
  0.891
frp1
Ferric reductase transmembrane component 1; Metalloreductase responsible for reducing extracellular iron and copper prior to import (By similarity). Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores (By similarity). Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane (By similarity). Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity) (564 aa)
     
   
  0.858
fio1
Iron transport multicopper oxidase fio1; Could be a iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport (622 aa)
     
   
  0.848
bfr1
Brefeldin A resistance protein; Confers hyper-resistance to brefeldin A (BFA), an inhibitor of intracellular protein transport. Could serve as an efflux pump of various antibiotics (1530 aa)
     
 
  0.801
SPAC24H6.11c.1
Uncharacterized protein C24H6.11c; Sulfate transmembrane transporter (predicted) (958 aa)
       
 
  0.733
vht1
Vitamin H transporter 1; Involved in uptake of biotin and desthiobiotin with the concomitant entry of protons (568 aa)
     
   
  0.710
SPBC215.01
TBC domain-containing protein C215.01; May act as a GTPase-activating protein for Rab family protein(s) (834 aa)
     
   
  0.639
rli1
Translation initiation factor rli1; Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits (By similarity) (593 aa)
     
   
  0.614
fep1
Iron-sensing transcription factor 1; Represses the expression of the iron transporter fio1 in response to high iron concentrations. Binds to the consensus sequence 5’-[AT]GATAA-3’. Also represses the expression of str1, str2 and str3 (564 aa)
     
   
  0.605
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 4896
Other names: CBS 356, CCRC 21461, DBVPG 6277, JCM 8274, MUCL 30245, NRRL Y-12796, S. pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombe, fission yeast
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