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clr6 protein (Schizosaccharomyces pombe) - STRING interaction network
"clr6" - Histone deacetylase (class I) Clr6 in Schizosaccharomyces pombe
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Predicted Interactions
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textmining
co-expression
protein homology
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clr6Histone deacetylase (class I) Clr6; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Has a role in chromatin assembly and chromosome segregation (405 aa)    
Predicted Functional Partners:
pst2
Clr6 histone deacetylase complex subunit Pst2; Has a role in chromatin assembly and chromosome segregation. Involved in the deacetylation of histones (1075 aa)
     
  0.999
alp13
MRG family Clr6 histone deacetylase complex subunit Alp13; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). Also involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains (337 aa)
     
  0.999
prw1
Clr6 histone deacetylase complex subunit Prw1; Has a role in chromatin assembly and chromosome segregation. Involved in the deacetylation of histones (431 aa)
     
  0.998
pst1
Clr6 histone deacetylase complex subunit Pst1; Has a role in modulating the nuclear import of TF1 virus-like particles. Essential for viability (1522 aa)
     
  0.998
clr3
Histone deacetylase (class II) Clr3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac- containing repressor complex (SHREC) (687 aa)
   
0.998
png2
ING family homolog Png2; Component of the clr6 histone deacetylase complex I’ responsible for the deacetylation of lysine residues on the N- terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Has a role in silencing of mating type genes (305 aa)
     
  0.996
sds3
Clr6 histone deacetylase complex subunit Sds3; Component of the clr6 histone deacetylase complex I responsible for the deacetylation of lysine residues on the N- terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (267 aa)
     
  0.996
cph2
Clr6 histone deacetylase associated PHD protein-2 Cph2 (607 aa)
     
  0.996
pst3
SIN3 family co-repressor Pst3 (1154 aa)
     
  0.995
clr1
Cryptic loci regulator Clr1; Regulates silencing of the mat2 and mat3 loci. Organizes the chromatin structure of the mating-type region where it also participates in establishing the ’cold spot’ for recombination. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC) (1238 aa)
     
  0.993
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 4896
Other names: S. pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombe, fission yeast
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