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pek1 protein (Schizosaccharomyces pombe) - STRING interaction network
"pek1" - MAP kinase kinase skh1/pek1 in Schizosaccharomyces pombe
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pek1MAP kinase kinase skh1/pek1; Involved in the mkh1 signal transduction pathway that plays a role in cell wall integrity. Activates spm1/pmk1 via phosphorylation (363 aa)    
Predicted Functional Partners:
pmk1
Mitogen-activated protein kinase spm1; Regulates cell integrity and functions coordinately with the protein kinase C pathway (pck1 and pck2). Involved the regulation of wall architecture, cell shape, cytokinesis in exponential and stationary phase, and metabolism of ions (422 aa)
   
 
0.994
mkh1
MAP kinase kinase kinase mkh1; May regulate cell morphology, cell wall integrity, salt resistance, cell cycle reentry from stationary-phase arrest, and filamentous growth in response to stress. Activates the MAP kinase kinase skh1/pek1 by phosphorylation (1116 aa)
     
0.989
spk1
Mitogen-activated protein kinase spk1; Involved in mating signal transduction pathway (372 aa)
   
 
0.982
cdc2
Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required for entry into S-phase and mitosis. When complexed with cig2, plays a role in G1-S phase transition. When activated and complexed with the cyclin cdc13, it leads to the onset of mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. Involved in cell cycle arrest induced by defective RNA splicing. Required for phosphorylation of dis1 to ensure accurate chromosome segregation and for the DNA damage checkpoint (297 aa)
   
0.928
byr1
Protein kinase byr1; Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it is phosphorylated by the byr2 protein kinase and that it can phosphorylate the spk1 kinase. When bound to bob1, is involved in the regulation of sexual differentiation (340 aa)
   
   
0.918
wsc1
Cell wall integrity and stress response component 1; Transmembrane receptor Wsc1 (predicted) (374 aa)
     
 
  0.918
rho1
GTP-binding protein rho1; Involved in the regulation of cell wall growth and actin cytoskeleton organization. Activates (1,3)-beta-D-glucan synthase (202 aa)
     
 
  0.911
rho2
GTP-binding protein rho2; Involved in cell morphogenesis, the maintenance of growth direction, control of polarity and of cell wall integrity. Regulates the synthesis of alpha-D-glucan through activation of pck2 (200 aa)
     
 
  0.902
pmp1
Tyrosine-protein phosphatase pmp1; Dual specificity phosphatase that dephosphorylates MAP kinase pmk1 on a Tyr. Has a role in chloride ion homeostasis by inactivating this pmk1 MAP kinase pathway (278 aa)
       
 
  0.880
sty1
Mitogen-activated protein kinase sty1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell- cycle G2/M control with changes in the extracellular environment that [...] (349 aa)
   
 
0.850
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 4896
Other names: CBS 356, CCRC 21461, DBVPG 6277, JCM 8274, MUCL 30245, NRRL Y-12796, S. pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombe, fission yeast
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