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spc7 protein (Schizosaccharomyces pombe) - STRING interaction network
"spc7" - Kinetochore protein spc7 in Schizosaccharomyces pombe
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
spc7Kinetochore protein spc7; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle (1364 aa)    
Predicted Functional Partners:
bub1
Checkpoint serine/threonine-protein kinase bub1; Involved in cell cycle checkpoint enforcement. Acts to stabilize the spindle during mitosis. Required for the correct localization of bub3 and mad3 to the kinetochore. Appears to have a role in chromosome segregation. Catalyzes the phosphorylation of bub3 (1044 aa)
     
  0.999
bub3
Mitotic checkpoint protein bub3; Involved in cell cycle checkpoint enforcement. Involved in recruitment of checkpoint proteins bub1 and mad3 to the kinetochores, ensuring correct spindle checkpoint function; Belongs to the WD repeat BUB3 family (320 aa)
       
  0.998
mad3
Mitotic spindle checkpoint component mad3; Has a role in transducing the anaphase inhibitory signal to the anaphase promoting complex (APC). Forms part of the mad2 feedback control (310 aa)
     
  0.998
nuf2
Kinetochore protein nuf2; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity; Belongs to the NUF2 family (441 aa)
     
  0.996
ndc80
Kinetochore protein ndc80; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity; Belongs to the NDC80/HEC1 family (624 aa)
     
  0.994
mis12
Centromere protein mis12; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Required for correct segregation of chromosomes and for maintaining the inner centromere structure; Belongs to the mis12 family (259 aa)
     
  0.992
ark1
Serine/threonine-protein kinase ark1; Required for the spindle checkpoint attachment response during spindle formation, kinetochore microtubule interactions and chromosome segregation during anaphase. Ark1 activity depends upon cut17 function and phosphorylation. Ark1 with bir1 is required for full-scale association with kinetochores and formation of a complex with mad3. Ark1 is also required for phosphorylation of histone H3 that accompanies chromosome condensation and condensin recruitment to mitotic chromatin. Ark1 with pic1 is required for the execution of cytokinesis; Belongs to t [...] (355 aa)
     
  0.992
spc25
Kinetochore protein spc25; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (238 aa)
     
  0.988
mis14
Kinetochore protein mis14; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Required for correct chromosome segregation where it has a role in the formation and/or maintenance of specialized chromatin at the centromere (210 aa)
       
  0.988
fta2
Kinetochore protein fta2; The Sim4 complex is required for loading the DASH complex onto the kinetochore via interaction with dad1. Fta2, fta3 and fta4 associate with the central core (cnt) and inner repeat (inr) region of the centromere (351 aa)
     
  0.985
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 4896
Other names: CBS 356, CCRC 21461, DBVPG 6277, JCM 8274, MUCL 30245, NRRL Y-12796, S. pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombe, fission yeast
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