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dcr1 protein (Schizosaccharomyces pombe) - STRING interaction network
"dcr1" - Protein Dicer in Schizosaccharomyces pombe
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Predicted Interactions
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textmining
co-expression
protein homology
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dcr1Protein Dicer; Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2 (1374 aa)    
Predicted Functional Partners:
ago1
Protein argonaute; Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2. Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis. Required for silencing at the centromeres and for initiation of transcriptionally silent heterochromatin at the mating type locus. Promotes histone H [...] (834 aa)
     
  0.999
pac1
Double-strand-specific pac1 ribonuclease; Digests double-stranded RNA. Converts long double- stranded RNAs into short oligonucleotides, leaving 5’-phosphates on their cleavage products. Probably inhibits mating and meiosis by degrading a specific mRNA required for sexual development (363 aa)
     
   
  0.989
clr4
Histone-lysine N-methyltransferase, H3 lysine-9 specific; Histone methyltransferase. Catalytic component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransfera [...] (490 aa)
     
 
  0.981
chp1
Chromo domain-containing protein 1; Component of the kinetochore which plays a role in stabilizing microtubules and so allowing accurate chromosome segregation. Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA- directed RNA polymerase (RDRC) complex (960 aa)
     
  0.978
tas3
RNA-induced transcriptional silencing complex protein tas3; Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex (549 aa)
       
  0.978
eri1
3’-5’ exonuclease eri1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Acts by degrading the 3’-overhangs of double- stranded short interfering RNAs (siRNAs). Represses the accumulation of heterochromatic siRNAs leading to negative regulation of the RNAi-mediated heterochromoatin assembly. Also involved in rRNA biogenesis, trimming the 5.8S ribosomal RNA (rRNA) from a slightly longer pre-5.8S RNA in the cytoplasm (313 aa)
       
 
  0.971
rdp1
RNA-dependent RNA polymerase 1; Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis. Required for both post-transcriptional and transcriptional gene silencing. Required for silencing at the centromeres and for initiation of transcriptionally silent heterochromatin at the mating type locus. Promotes histone H3 ’Lys-10’ methylation necessary for centromere function. Required for recruitment of swi6 and cohesin to an ectopic dg repeat. A mem [...] (1215 aa)
     
 
  0.955
SPBC725.08
zf-C2H2 type zinc finger protein, implicated in RNAi (predicted) (609 aa)
     
 
  0.954
dhp1
5’-3’ exoribonuclease 2; Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II (By similarity). Essential for vegetative cell growth and chromosome segregation. Possesses 5’->3’ exoribonuclease activity; Belongs to the 5’-3’ exonuclease family. XRN2/RAT1 subfamily (991 aa)
     
 
  0.939
sir2
NAD-dependent histone deacetylase sir2; Involved in silencing within the mating-type region, at the telomeres, and according to PubMed-12867036 also within centromeric DNA regions. Required for the localization of swi6 to the telomeres, silent mating type region, and according to PubMed-12867036 to the centromeric DNA regions. According to PubMed-15545655 not required for the localization of swi6 to centromeric foci. Deacetylates histone H3 on ’Lys-9’ and ’Lys-16’ of histone H4. This has a direct role in heterochromatin assembly; Belongs to the sirtuin family. Class I subfamily (475 aa)
     
 
  0.930
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 4896
Other names: CBS 356, CCRC 21461, DBVPG 6277, JCM 8274, MUCL 30245, NRRL Y-12796, S. pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombe, fission yeast
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