STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
psmB1Proteasome subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (202 aa)    
Predicted Functional Partners:
pan
Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...]
  
 0.929
psmB2
Proteasome subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
  
 
0.907
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate.
   
 0.904
psmA
Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.885
DKAM_0862
50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.858
DKAM_0433
Protease; COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.
    
 0.670
DKAM_1033
Thermosome subunit alpha; COG0459 Chaperonin GroEL (HSP60 family); Belongs to the TCP-1 chaperonin family.
 
 
 0.665
DKAM_0181
AAA family ATPase.
  
 0.663
DKAM_0042
Cell division control protein 48, AAA family.
  
 0.661
DKAM_1070
AAA family ATPase, CDC48 subfamily.
  
 0.661
Your Current Organism:
Desulfurococcus amylolyticus
NCBI taxonomy Id: 490899
Other names: D. amylolyticus 1221n, Desulfurococcus amylolyticus 1221n, Desulfurococcus kamchatkensis 1221n, Proteinoruptor kamchatkensis 1221n
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