node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aflv_0559 | Aflv_1373 | Aflv_0559 | Aflv_1373 | Membrane protein connecting MutS with cell-division Z-ring. | Uncharacterized protein conserved in bacteria; Belongs to the HesB/IscA family. | 0.543 |
Aflv_0559 | Aflv_2499 | Aflv_0559 | Aflv_2499 | Membrane protein connecting MutS with cell-division Z-ring. | Esterase/lipase. | 0.510 |
Aflv_0559 | lipL | Aflv_0559 | Aflv_2759 | Membrane protein connecting MutS with cell-division Z-ring. | Lipoate-protein ligase A; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | 0.704 |
Aflv_0559 | mecA | Aflv_0559 | Aflv_2125 | Membrane protein connecting MutS with cell-division Z-ring. | Negative regulator of genetic competence, sporulation and motility; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.573 |
Aflv_1373 | Aflv_0559 | Aflv_1373 | Aflv_0559 | Uncharacterized protein conserved in bacteria; Belongs to the HesB/IscA family. | Membrane protein connecting MutS with cell-division Z-ring. | 0.543 |
Aflv_1373 | Aflv_2499 | Aflv_1373 | Aflv_2499 | Uncharacterized protein conserved in bacteria; Belongs to the HesB/IscA family. | Esterase/lipase. | 0.594 |
Aflv_1373 | lipL | Aflv_1373 | Aflv_2759 | Uncharacterized protein conserved in bacteria; Belongs to the HesB/IscA family. | Lipoate-protein ligase A; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | 0.772 |
Aflv_2499 | Aflv_0559 | Aflv_2499 | Aflv_0559 | Esterase/lipase. | Membrane protein connecting MutS with cell-division Z-ring. | 0.510 |
Aflv_2499 | Aflv_1373 | Aflv_2499 | Aflv_1373 | Esterase/lipase. | Uncharacterized protein conserved in bacteria; Belongs to the HesB/IscA family. | 0.594 |
Aflv_2499 | lipL | Aflv_2499 | Aflv_2759 | Esterase/lipase. | Lipoate-protein ligase A; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | 0.720 |
Aflv_2499 | mecA | Aflv_2499 | Aflv_2125 | Esterase/lipase. | Negative regulator of genetic competence, sporulation and motility; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.594 |
bkdB | gcvH | Aflv_0964 | Aflv_2478 | Branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase). | Glycine cleavage system H protein (lipoate-binding); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.767 |
bkdB | lipA | Aflv_0964 | Aflv_2425 | Branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase). | Lipoic acid synthetase (lipoate synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.609 |
bkdB | lipL | Aflv_0964 | Aflv_2759 | Branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase). | Lipoate-protein ligase A; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | 0.684 |
bkdB | lipM | Aflv_0964 | Aflv_0919 | Branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase). | Lipoate-protein ligase A; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. | 0.656 |
bkdB | pta | Aflv_0964 | Aflv_2760 | Branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase). | Phosphotransacetylase. | 0.927 |
gcvH | bkdB | Aflv_2478 | Aflv_0964 | Glycine cleavage system H protein (lipoate-binding); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase). | 0.767 |
gcvH | lipA | Aflv_2478 | Aflv_2425 | Glycine cleavage system H protein (lipoate-binding); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Lipoic acid synthetase (lipoate synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.953 |
gcvH | lipL | Aflv_2478 | Aflv_2759 | Glycine cleavage system H protein (lipoate-binding); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Lipoate-protein ligase A; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | 0.925 |
gcvH | lipM | Aflv_2478 | Aflv_0919 | Glycine cleavage system H protein (lipoate-binding); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Lipoate-protein ligase A; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. | 0.937 |