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MUM2 protein (Saccharomyces cerevisiae) - STRING interaction network
"MUM2" - Cytoplasmic protein essential for meiotic DNA replication and sporulation in Saccharomyces cerevisiae
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second shell of interactors
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Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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MUM2Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex; Component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation on some mRNAs during meiosis and is required for sporulation (366 aa)    
Predicted Functional Partners:
IME4
Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids; Catalytic component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation on some mRNAs during meiosis and is required for sporulation. M6A, which takes place on the adenosine of 5’-[AG]GAC-3’ consensus sites of some mRNAs, is probably required to initiate sporulation. Positive regulator for IME2 (600 aa)
       
    0.943
SLZ1
Sporulation-specific protein with a leucine zipper motif; Component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation on some mRNAs during meiosis and is required for sporulation. In the complex, mediates the entry of the MIS complex in nucleolus, where methylation takes place (298 aa)
         
    0.900
SPO14
Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participat /.../transcription initiation and/or early elongation of specific genes; interacts with "foot domain" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; Required for meiosis and spore formation. Seems to be involved in the coordinate induction of late meiotic events [...] (1683 aa)
       
 
  0.828
YGL036W
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene (909 aa)
       
      0.804
POL1
Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis; Catalytic component of DNA polymerase alpha, which in complex with DNA primase (DNA polymerase alpha-primase) consitutes a replicative polymerase. POL1 has a role in promoting telomere replication during interaction with CDC13 (1468 aa)
       
      0.454
ORC2
Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p; Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication (620 aa)
       
      0.454
ENO2
Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose (437 aa)
           
  0.418
ENO1
Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose (437 aa)
           
  0.418
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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