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AMN1 protein (Saccharomyces cerevisiae) - STRING interaction network
"AMN1" - Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability in Saccharomyces cerevisiae
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Predicted Interactions
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textmining
co-expression
protein homology
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AMN1Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN); Negative regulator of the mitotic exit network (MEN), required for multiple cell cycle checkpoints. Acts in the daughter cell to inhibit the mitotic exit pathway once MEN has executed its function. Through its binding ability to TEM1, interferes with the TEM1-CDC5 association, required for CDC5 kinase activation and MEN activation. Required for daughter cell separation and chrom [...] (549 aa)    
Predicted Functional Partners:
SCW11
Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p; Involved in cell separation (542 aa)
     
   
  0.964
BFA1
Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis; Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis. This cell-cycle arrest depends upon inhibition of the G-protein TEM1 by the BFA1/BUB2 complex (574 aa)
       
 
  0.956
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family; Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions and plays a role in septation (420 aa)
     
   
  0.942
BUB2
Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage; Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis. This cell-cycle arrest depends upon inhibition of the GTP-binding protein TEM1 by the BFA1/BUB2 complex (306 aa)
       
 
  0.934
DSE2
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP; Involved in pseudohyphal growth, cell wall metabolism and required for the separation of the mother and daughter cells (325 aa)
     
   
  0.922
CDC5
Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate; Protein kinase required for the cell cycle where it is involved in mitotic exit. A component of the fear (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Phosphorylates SCC1/MCD1 and NET1 (705 aa)
       
 
  0.920
DSE1
Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; Involved in cell wall metabolism and required for the separation of the mother and daughter cells (573 aa)
     
   
  0.905
CDC55
Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; homolog of mammalian B55; Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cell [...] (526 aa)
       
 
  0.896
EGT2
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner; Seems to be involved in the correct timing of cell separation after cytokinesis, as separation of mutant daughter cells is delayed. Could either be an enzyme necessary for glucans- degradation of the cell wall at the neck region between mother and daughter cells or a regulatory protein controlling this metabolic step (1041 aa)
     
   
  0.894
PPH22
Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; Exact function not known, phosphatase 2A performs an essential cellular function (377 aa)
       
 
  0.878
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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