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SPO23 protein (Saccharomyces cerevisiae) - STRING interaction network
"SPO23" - Protein of unknown function in Saccharomyces cerevisiae
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SPO23Protein of unknown function; associates with meiosis-specific protein Spo1p; Regulates expression of PIS1 (523 aa)    
Predicted Functional Partners:
LDB19
Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; localization changes in response to nutrient levels; null mutant has reduced affinity for alcian blue dye; May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface. Involved in the resistance to EDTA, cadmium chloride, cycloheximide, 6-dimethylaminopurine, methyl caffeate, beta-chloro-L-alanine, caffeine and cerulenin (818 aa)
           
  0.679
SPO1
Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B; Regulates spindle pole duplication in meiosis I, but not in mitosis. Required for meiosis I, meiosis II chromosome segregation and spore formation. Binds phosphatidylinositol (4)P mono- and polyphosphates (631 aa)
       
 
  0.655
ROG3
Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; Involved in resistance to GST substrate o-dinitrobenzene (o-DNB) (733 aa)
           
  0.642
ALY2
Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli (1046 aa)
           
  0.622
ALY1
Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli (915 aa)
           
  0.621
ART5
Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli (586 aa)
           
  0.578
CSR2
Nuclear protein proposed to regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; Transcription factor involved in the regulation of fermentation and aerobic oxidation. Acts as a repressor of CYC1, which is involved in electron flow through the mitochondria under aerobic condition. Required for pseudohyphal formation upon nitrogen starvation. May be involved in viability at stationary phase and aging (1121 aa)
           
  0.572
YML082W
Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not /.../ential gene; Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma- replacement reaction. In the absence of thiol, catalyzes gamma- elimination to form 2-oxobutanoate, succinate and ammonia (By similarity) (649 aa)
           
  0.503
ROD1
Membrane protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene,zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; Mediates resistance to o-dinitrobenzene, calcium and zinc (837 aa)
           
  0.485
YDR442W
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (130 aa)
           
  0.483
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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