node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERC1 | YCR023C | YHR032W | YCR023C | Ethionine resistance-conferring protein 1; Member of the multi-drug and toxin extrusion (MATE) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine. | Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene. | 0.520 |
MRP4 | PUF3 | YHL004W | YLL013C | Mitochondrial ribosomal protein of the small subunit. | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | 0.769 |
MRP4 | SLM5 | YHL004W | YCR024C | Mitochondrial ribosomal protein of the small subunit. | Asparagine--tRNA ligase, mitochondrial; Mitochondrial asparaginyl-tRNA synthetase. | 0.467 |
MRP4 | TMC1 | YHL004W | YOR052C | Mitochondrial ribosomal protein of the small subunit. | AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress. | 0.784 |
MRP4 | YCR023C | YHL004W | YCR023C | Mitochondrial ribosomal protein of the small subunit. | Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene. | 0.470 |
NPP1 | YCR023C | YCR026C | YCR023C | Ectonucleotide pyrophosphatase/phosphodiesterase 1; Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; NPP1 has a paralog, NPP2, that arose from the whole genome duplication, and an npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants. | Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene. | 0.488 |
NPP1 | YCR025C | YCR026C | YCR025C | Ectonucleotide pyrophosphatase/phosphodiesterase 1; Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; NPP1 has a paralog, NPP2, that arose from the whole genome duplication, and an npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants. | Uncharacterized protein YCR025C; Putative protein of unknown function; conserved across S. cerevisiae strains; YCR025C is not an essential gene. | 0.875 |
PUF3 | MRP4 | YLL013C | YHL004W | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | Mitochondrial ribosomal protein of the small subunit. | 0.769 |
PUF3 | TMC1 | YLL013C | YOR052C | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress. | 0.510 |
PUF3 | YCR023C | YLL013C | YCR023C | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene. | 0.510 |
SLM5 | MRP4 | YCR024C | YHL004W | Asparagine--tRNA ligase, mitochondrial; Mitochondrial asparaginyl-tRNA synthetase. | Mitochondrial ribosomal protein of the small subunit. | 0.467 |
SLM5 | YCR023C | YCR024C | YCR023C | Asparagine--tRNA ligase, mitochondrial; Mitochondrial asparaginyl-tRNA synthetase. | Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene. | 0.701 |
SLM5 | YCR025C | YCR024C | YCR025C | Asparagine--tRNA ligase, mitochondrial; Mitochondrial asparaginyl-tRNA synthetase. | Uncharacterized protein YCR025C; Putative protein of unknown function; conserved across S. cerevisiae strains; YCR025C is not an essential gene. | 0.792 |
TMC1 | MRP4 | YOR052C | YHL004W | AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress. | Mitochondrial ribosomal protein of the small subunit. | 0.784 |
TMC1 | PUF3 | YOR052C | YLL013C | AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress. | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | 0.510 |
TMC1 | YCR023C | YOR052C | YCR023C | AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress. | Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene. | 0.512 |
TMC1 | YDR090C | YOR052C | YDR090C | AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress. | Uncharacterized membrane protein YDR090C; Putative protein of unknown function. | 0.557 |
TMC1 | YFR016C | YOR052C | YFR016C | AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress. | Uncharacterized protein YFR016C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFR016C is not an essential gene. | 0.519 |
YCR023C | ERC1 | YCR023C | YHR032W | Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene. | Ethionine resistance-conferring protein 1; Member of the multi-drug and toxin extrusion (MATE) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine. | 0.520 |
YCR023C | MRP4 | YCR023C | YHL004W | Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene. | Mitochondrial ribosomal protein of the small subunit. | 0.470 |