STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IMG2Mitochondrial ribosomal protein of the large subunit; conserved in metazoa, with similarity to human mitochondrial ribosomal protein MRPL49. (146 aa)    
Predicted Functional Partners:
IMG1
Mitochondrial ribosomal protein of the large subunit; required for respiration and for maintenance of the mitochondrial genome.
   
 
 0.999
MRPL3
Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; human MRPL44 deficiency results in inefficient assembly of the mitochondrial ribosome, and in tissue-specific respiratory chain deficiency, manifesting as either Complex I+Complex IV or Complex IV deficiency, depending on a cell type; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL44 subfamily.
   
 
 0.999
MRPL10
Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels.
   
 
 0.999
MRPL51
Mitochondrial ribosomal protein of the large subunit.
   
 
 0.999
MRP20
Mitochondrial ribosomal protein of the large subunit.
   
 
 0.998
MRPL9
Mitochondrial ribosomal protein of the large subunit.
   
 
 0.998
MRPL8
Mitochondrial ribosomal protein of the large subunit.
   
 
 0.998
YML6
Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins.
   
 
 0.998
MRPL33
Mitochondrial ribosomal protein of the large subunit.
   
 
 0.998
MRPL17
Mitochondrial ribosomal protein of the large subunit.
   
 
 0.998
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.