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RDS1 protein (Saccharomyces cerevisiae) - STRING interaction network
"RDS1" - Zinc cluster transcription factor involved in conferring resistance to cycloheximide in Saccharomyces cerevisiae
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Predicted Interactions
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textmining
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RDS1Zinc cluster transcription factor involved in conferring resistance to cycloheximide; Zinc cluster transcription factor involved in resistance to cycloheximide (832 aa)    
Predicted Functional Partners:
RSP5
E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates an /.../dy; ubiquitylates Sec23p; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general a [...] (809 aa)
       
      0.699
UBP2
Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity; Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an N-terminal extension to ubiquitin. Removes ubiquitin chains that initiate proteolysis of FZO1 and inhibit mitochondrial fusion (1272 aa)
       
      0.698
ADE6
Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the ’de novo’ purine nucleotide biosynthetic pathway; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity) (1358 aa)
       
      0.695
RUP1
Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; Modulates the activity of the RSP5 HECT ubiquitin- protein ligase through its mediation of the interaction between RSP5 and the deubiquitinase UBP2. Involved in regulation of cell wall homeostasis (671 aa)
       
      0.684
LDB19
Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; localization changes in response to nutrient levels; null mutant has reduced affinity for alcian blue dye; May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface. Involved in the resistance to EDTA, cadmium chloride, cycloheximide, 6-dimethylaminopurine, methyl caffeate, beta-chloro-L-alanine, caffeine and cerulenin (818 aa)
       
      0.682
NPR1
Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; Nutrient-regulated protein kinase that promotes the activity of at least 6 distinct transport systems for nitrogenous nutrients under conditions of nitrogen catabolite derepression. Under poor nitrogen growth conditions, required for post-Golgi sorting of the general amino acid permease GAP1 and the three known ammonia permeases, MEP1/2/3, to the plasma membrane. Contributes also to the stability and the retention of GAP1 at the plas [...] (790 aa)
       
      0.675
YHR131C
Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study (850 aa)
       
      0.612
EDS1
Putative zinc cluster protein; YBR033W is not an essential gene (919 aa)
           
  0.544
YLR278C
Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene (1341 aa)
           
  0.543
ERT1
Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition; Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes like PCK1. Involved in restriction of Ty1 transposition (529 aa)
           
  0.519
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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