node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRR2 | PRP8 | YER172C | YHR165C | Pre-mRNA-splicing helicase BRR2; RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD. | Pre-mRNA-splicing factor 8; Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer. | 0.999 |
BRR2 | YDL085C-A | YER172C | YDL085C-A | Pre-mRNA-splicing helicase BRR2; RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD. | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | 0.670 |
BUD32 | YDL085C-A | YGR262C | YDL085C-A | Protein kinase; component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; Pyrococcus Bud32 ortholog functions as a P-loop ATPase rather than a protein kinase in the context of the complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; mutation is functionally complemented by human TP53RK. | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | 0.475 |
BUD32 | YIL156W-B | YGR262C | YIL156W-B | Protein kinase; component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; Pyrococcus Bud32 ortholog functions as a P-loop ATPase rather than a protein kinase in the context of the complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; mutation is functionally complemented by human TP53RK. | Uncharacterized protein YIL156W-B; Putative protein of unknown function; originally identified based on homology to <i>Ashbya gossypii</i> and other related yeasts; SWAT-GFP and mCherry fusion proteins localize to the vacuole, while SWAT-GFP fusion also localizes to the endoplasmic reticulum. | 0.430 |
NHP6A | YDL085C-A | YPR052C | YDL085C-A | Non-histone chromosomal protein 6A; High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress. | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | 0.632 |
PRP8 | BRR2 | YHR165C | YER172C | Pre-mRNA-splicing factor 8; Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer. | Pre-mRNA-splicing helicase BRR2; RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD. | 0.999 |
PRP8 | YDL085C-A | YHR165C | YDL085C-A | Pre-mRNA-splicing factor 8; Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer. | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | 0.593 |
TMA7 | YDL085C-A | YLR262C-A | YDL085C-A | Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress; Belongs to the TMA7 family. | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | 0.496 |
YDL085C-A | BRR2 | YDL085C-A | YER172C | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | Pre-mRNA-splicing helicase BRR2; RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD. | 0.670 |
YDL085C-A | BUD32 | YDL085C-A | YGR262C | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | Protein kinase; component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; Pyrococcus Bud32 ortholog functions as a P-loop ATPase rather than a protein kinase in the context of the complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; mutation is functionally complemented by human TP53RK. | 0.475 |
YDL085C-A | NHP6A | YDL085C-A | YPR052C | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | Non-histone chromosomal protein 6A; High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress. | 0.632 |
YDL085C-A | PRP8 | YDL085C-A | YHR165C | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | Pre-mRNA-splicing factor 8; Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer. | 0.593 |
YDL085C-A | TMA7 | YDL085C-A | YLR262C-A | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress; Belongs to the TMA7 family. | 0.496 |
YDL085C-A | YDL159W-A | YDL085C-A | YDL159W-A | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | Uncharacterized protein YDL159W-A; Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species. | 0.662 |
YDL085C-A | YIL156W-B | YDL085C-A | YIL156W-B | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | Uncharacterized protein YIL156W-B; Putative protein of unknown function; originally identified based on homology to <i>Ashbya gossypii</i> and other related yeasts; SWAT-GFP and mCherry fusion proteins localize to the vacuole, while SWAT-GFP fusion also localizes to the endoplasmic reticulum. | 0.808 |
YDL085C-A | YKL096C-B | YDL085C-A | YKL096C-B | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | Uncharacterized protein YKL096C-B; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. | 0.667 |
YDL085C-A | YKL183C-A | YDL085C-A | YKL183C-A | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | Uncharacterized protein YKL183C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. | 0.661 |
YDL159W-A | YDL085C-A | YDL159W-A | YDL085C-A | Uncharacterized protein YDL159W-A; Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species. | SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family. | 0.662 |
YDL159W-A | YKL096C-B | YDL159W-A | YKL096C-B | Uncharacterized protein YDL159W-A; Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species. | Uncharacterized protein YKL096C-B; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching. | 0.971 |
YDL159W-A | YKL183C-A | YDL159W-A | YKL183C-A | Uncharacterized protein YDL159W-A; Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species. | Uncharacterized protein YKL183C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. | 0.954 |