node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIM17 | YDR182W-A | YHL021C | YDR182W-A | Probable oxidoreductase AIM17; Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss; Belongs to the gamma-BBH/TMLD family | Uncharacterized protein YDR182W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR | 0.585 |
COQ2 | YDR182W-A | YNR041C | YDR182W-A | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Para hydroxybenzoate polyprenyl transferase; catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; human COQ2, mutations in which are implicated in an increased risk of mutiple-system atrophy, can complement a yeast coq2 null mutant | Uncharacterized protein YDR182W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR | 0.556 |
GDT1 | YDR182W-A | YBR187W | YDR182W-A | GCR1-dependent translation factor 1; Calcium transporter localized to the cis- and medial-Golgi apparatus; required for protein glycosylation; GFP-fusion protein localizes to the vacuole; TMEM165, a human gene which causes Congenital Disorders of Glycosylation is orthologous and functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression reduced in a gcr1 null mutant; Belongs to the GDT1 family | Uncharacterized protein YDR182W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR | 0.553 |
MTL1 | YDR182W-A | YGR023W | YDR182W-A | Protein MTL1; Putative plasma membrane sensor; involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p; MTL1 has a paralog, MID2, that arose from the whole genome duplication | Uncharacterized protein YDR182W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR | 0.520 |
OPY2 | YDR169C-A | YPR075C | YDR169C-A | Protein OPY2; Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress | Uncharacterized protein YDR169C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR | 0.525 |
OPY2 | YDR182W-A | YPR075C | YDR182W-A | Protein OPY2; Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress | Uncharacterized protein YDR182W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR | 0.569 |
RPL19B | RPL34A | YBL027W | YER056C-A | Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication | Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication | 0.999 |
RPL19B | RPL34B | YBL027W | YIL052C | Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication | Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication | 0.999 |
RPL19B | YDR169C-A | YBL027W | YDR169C-A | Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication | Uncharacterized protein YDR169C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR | 0.567 |
RPL19B | YDR182W-A | YBL027W | YDR182W-A | Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication | Uncharacterized protein YDR182W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR | 0.472 |
RPL34A | RPL19B | YER056C-A | YBL027W | Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication | Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication | 0.999 |
RPL34A | RPL34B | YER056C-A | YIL052C | Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication | Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication | 0.998 |
RPL34A | YDR169C-A | YER056C-A | YDR169C-A | Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication | Uncharacterized protein YDR169C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR | 0.618 |
RPL34A | YDR182W-A | YER056C-A | YDR182W-A | Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication | Uncharacterized protein YDR182W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR | 0.499 |
RPL34B | RPL19B | YIL052C | YBL027W | Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication | Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication | 0.999 |
RPL34B | RPL34A | YIL052C | YER056C-A | Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication | Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication | 0.998 |
RPL34B | YDR169C-A | YIL052C | YDR169C-A | Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication | Uncharacterized protein YDR169C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR | 0.618 |
RPL34B | YDR182W-A | YIL052C | YDR182W-A | Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication | Uncharacterized protein YDR182W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR | 0.499 |
YDR169C-A | OPY2 | YDR169C-A | YPR075C | Uncharacterized protein YDR169C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR | Protein OPY2; Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress | 0.525 |
YDR169C-A | RPL19B | YDR169C-A | YBL027W | Uncharacterized protein YDR169C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR | Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication | 0.567 |