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LSO2 protein (Saccharomyces cerevisiae) - STRING interaction network
"LSO2" - Putative protein of unknown function in Saccharomyces cerevisiae
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LSO2Putative protein of unknown function (92 aa)    
Predicted Functional Partners:
LSO1
Putative protein of unknown function, originally identified as a syntenic homolog of an <i>Ashbya gossypii</i> gene (93 aa)
       
 
  0.927
FRA2
Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel; Involved in the regulation of the iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis. May be involved in mitochondrial organization and biogenesis (120 aa)
           
  0.578
HMX1
ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants; Plays an important role in the degradation of heme under conditions of iron deprivation (317 aa)
           
  0.519
GDT1
Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; May be involved in ribosome biogenesis. Has also been proposed to play a role in calcium homeostasis (PubMed-23569283) (280 aa)
           
  0.519
CIR2
Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response; Accepts electrons from ETF and reduces ubiquinone (631 aa)
           
  0.517
FRA1
Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation; Involved in the regulation of the iron regulon in responss to decreased mitochondrial iron-sulfur cluster synthesis (749 aa)
           
  0.470
GRX4
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (By similarity). Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (Probable) (244 aa)
           
  0.448
TYW1
Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3’-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticod /.../eractions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron; Component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine [...] (810 aa)
           
  0.418
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3’-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; Binds to specific AU-rich elements (ARE) in the 3’- untranslated region of target mRNAs and promotes their degradation. In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways. Recruits the DHH1 helicase to the SDH4 mRNA and promotes SDH4 mRNA decay. Also destabilizes target mRNA by modulating 3’-end processing, creating extended trans [...] (285 aa)
           
  0.418
CRS5
Copper-binding metallothionein, required for wild-type copper resistance; Critical role in copper (specific) homeostasis and detoxification. May protect by directly chelating and sequestering copper ions (69 aa)
           
  0.418
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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