LSO2 protein (Saccharomyces cerevisiae) - STRING interaction network
"LSO2" - Putative protein of unknown function in Saccharomyces cerevisiae
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LSO2Putative protein of unknown function (92 aa)    
Predicted Functional Partners:
Putative protein of unknown function, originally identified as a syntenic homolog of an <i>Ashbya gossypii</i> gene (93 aa)
Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel; Involved in the regulation of the iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis. May be involved in mitochondrial organization and biogenesis (120 aa)
ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants; Plays an important role in the degradation of heme under conditions of iron deprivation (317 aa)
Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; May be involved in ribosome biogenesis. Has also been proposed to play a role in calcium homeostasis (PubMed-23569283) (280 aa)
Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response; Accepts electrons from ETF and reduces ubiquinone (631 aa)
Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation; Involved in the regulation of the iron regulon in responss to decreased mitochondrial iron-sulfur cluster synthesis (749 aa)
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (By similarity). Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (Probable) (244 aa)
Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3’-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticod /.../eractions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron; Component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine [...] (810 aa)
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3’-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; Binds to specific AU-rich elements (ARE) in the 3’- untranslated region of target mRNAs and promotes their degradation. In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways. Recruits the DHH1 helicase to the SDH4 mRNA and promotes SDH4 mRNA decay. Also destabilizes target mRNA by modulating 3’-end processing, creating extended trans [...] (285 aa)
Copper-binding metallothionein, required for wild-type copper resistance; Critical role in copper (specific) homeostasis and detoxification. May protect by directly chelating and sequestering copper ions (69 aa)
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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