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EFM1 protein (Saccharomyces cerevisiae) - STRING interaction network
"EFM1" - Lysine methyltransferase in Saccharomyces cerevisiae
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
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textmining
co-expression
protein homology
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EFM1Lysine methyltransferase; involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that monomethylates elongation factor 1-alpha (TEF1/TEF2) at ’Lys-30’ (585 aa)    
Predicted Functional Partners:
EFM2
S-adenosylmethionine-dependent methyltransferase; belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 2 (EFT1/EFT2) at ’Lys-613’ and methylates elongation factor 3A (YEF3) (419 aa)
     
   
  0.902
RKM2
Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that trimethylates 60S ribosomal protein L12 (RPL12A and RPL12B) at ’Lys-4’ and ’Lys-11’ (479 aa)
           
  0.889
RKM4
Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that monomethylates 60S ribosomal protein L42 (RPL42A and RPL42B) at ’Lys-55’ (494 aa)
           
  0.808
RMT2
Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; S-adenosyl-L-methionine-dependent protein-arginine N- methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins (PubMed-9873020). Monomethylates ribosomal protein L12 (RPL12A/RPL12B) at ’Arg-67’ (PubMed-11856739) (412 aa)
     
   
  0.775
RKM3
Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that monomethylates 60S ribosomal protein L42 (RPL42A and RPL42B) at ’Lys-40’ (552 aa)
           
  0.766
CTM1
Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth; Methyltransferase which mediates trimethylation of ’Lys- 78’ of cytochrome c (CYC1) (585 aa)
           
  0.760
RSA4
WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus; Involved in ribosome biogenesis. Required for processing and efficient intra-nuclear transport of pre-60S ribosomal subunits. Interacts with the AAA-ATPase Midasin (MDN1/REA1), which is essential for the ATP-dependent dissociation of a group of nonribosomal factors from the pre-60S particle (515 aa)
     
      0.728
EFM4
Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1- alpha (TEF1 and TEF2) at ’Lys-316’. May play a role in intracellular transport (257 aa)
     
   
  0.714
GCN20
Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA; Acts as a positive activator of the GCN2 protein kinase activity in response to amino acid starvation (PubMed-7621831). Component of the GCN1-GCN20 complex that forms a complex with GCN2 on translating ribosomes; during this process, GCN20 helps GCN1 to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of GCN2, and hence stimulating GCN2 kinase activity (PubMed-7621831, PubMed-9 [...] (752 aa)
     
      0.715
UTP14
Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; Involved in nucleolar processing of pre-18S ribosomal RNA (899 aa)
     
      0.714
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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