node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAR2 | YCL048W-A | YLR438W | YCL048W-A | L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant. | Uncharacterized protein YCL048W-A; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCL048W-A has a paralog, YDR524C-B, that arose from the whole genome duplication. | 0.404 |
CAR2 | YIL002W-A | YLR438W | YIL002W-A | L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant. | Uncharacterized protein YIL002W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. | 0.448 |
FIN1 | YIL002W-A | YDR130C | YIL002W-A | Filament protein FIN1; Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress. | Uncharacterized protein YIL002W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. | 0.459 |
FMP45 | YCL048W-A | YDL222C | YCL048W-A | SUR7 family protein FMP45; Integral membrane protein localized to mitochondria; required for sporulation and maintaining sphingolipid content; similar to SUR7; FMP45 has a paralog, YNL194C, that arose from the whole genome duplication. | Uncharacterized protein YCL048W-A; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCL048W-A has a paralog, YDR524C-B, that arose from the whole genome duplication. | 0.550 |
FMP45 | YIL002W-A | YDL222C | YIL002W-A | SUR7 family protein FMP45; Integral membrane protein localized to mitochondria; required for sporulation and maintaining sphingolipid content; similar to SUR7; FMP45 has a paralog, YNL194C, that arose from the whole genome duplication. | Uncharacterized protein YIL002W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. | 0.516 |
MLP2 | NAB2 | YIL149C | YGL122C | Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; MLP2 has a paralog, MLP1, that arose from the whole genome duplication. | Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; stimulates RNA polymerase III transcription by enhancing TFIIIB binding to promoters; protects mRNA against decay by the nuclear exosome in a poly(A)-tail-dependent manner; involved in forming export-competent mRNPs in the nucleus; autoregulates mRNA levels; NLS binds Kap104p; protein abundance increases under DNA replication stress; related to human hnRNPs; Belongs to the NAB2 family. | 0.852 |
MLP2 | YIL002W-A | YIL149C | YIL002W-A | Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; MLP2 has a paralog, MLP1, that arose from the whole genome duplication. | Uncharacterized protein YIL002W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. | 0.422 |
NAB2 | MLP2 | YGL122C | YIL149C | Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; stimulates RNA polymerase III transcription by enhancing TFIIIB binding to promoters; protects mRNA against decay by the nuclear exosome in a poly(A)-tail-dependent manner; involved in forming export-competent mRNPs in the nucleus; autoregulates mRNA levels; NLS binds Kap104p; protein abundance increases under DNA replication stress; related to human hnRNPs; Belongs to the NAB2 family. | Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; MLP2 has a paralog, MLP1, that arose from the whole genome duplication. | 0.852 |
NAB2 | YIL002W-A | YGL122C | YIL002W-A | Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; stimulates RNA polymerase III transcription by enhancing TFIIIB binding to promoters; protects mRNA against decay by the nuclear exosome in a poly(A)-tail-dependent manner; involved in forming export-competent mRNPs in the nucleus; autoregulates mRNA levels; NLS binds Kap104p; protein abundance increases under DNA replication stress; related to human hnRNPs; Belongs to the NAB2 family. | Uncharacterized protein YIL002W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. | 0.510 |
PMP3 | YBR230W-A | YDR276C | YBR230W-A | Small plasma membrane protein; confers resistance to amphotericin B and is a potential target of this common antifungal drug; related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature; not essential for viability; deletion causes hyperpolarization of the plasma membrane potential; Belongs to the UPF0057 (PMP3) family. | Putative protein of unknown function; YBR230W-A has a paralog, COQ8, that arose from the whole genome duplication. | 0.462 |
PMP3 | YCL048W-A | YDR276C | YCL048W-A | Small plasma membrane protein; confers resistance to amphotericin B and is a potential target of this common antifungal drug; related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature; not essential for viability; deletion causes hyperpolarization of the plasma membrane potential; Belongs to the UPF0057 (PMP3) family. | Uncharacterized protein YCL048W-A; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCL048W-A has a paralog, YDR524C-B, that arose from the whole genome duplication. | 0.514 |
PMP3 | YIL002W-A | YDR276C | YIL002W-A | Small plasma membrane protein; confers resistance to amphotericin B and is a potential target of this common antifungal drug; related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature; not essential for viability; deletion causes hyperpolarization of the plasma membrane potential; Belongs to the UPF0057 (PMP3) family. | Uncharacterized protein YIL002W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. | 0.570 |
SCS3 | YCL048W-A | YGL126W | YCL048W-A | FIT family protein SCS3; Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol. | Uncharacterized protein YCL048W-A; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCL048W-A has a paralog, YDR524C-B, that arose from the whole genome duplication. | 0.414 |
SCS3 | YIL002W-A | YGL126W | YIL002W-A | FIT family protein SCS3; Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol. | Uncharacterized protein YIL002W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. | 0.478 |
TRM44 | YIL002W-A | YPL030W | YIL002W-A | tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene. | Uncharacterized protein YIL002W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. | 0.418 |
YBR230W-A | PMP3 | YBR230W-A | YDR276C | Putative protein of unknown function; YBR230W-A has a paralog, COQ8, that arose from the whole genome duplication. | Small plasma membrane protein; confers resistance to amphotericin B and is a potential target of this common antifungal drug; related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature; not essential for viability; deletion causes hyperpolarization of the plasma membrane potential; Belongs to the UPF0057 (PMP3) family. | 0.462 |
YBR230W-A | YCL048W-A | YBR230W-A | YCL048W-A | Putative protein of unknown function; YBR230W-A has a paralog, COQ8, that arose from the whole genome duplication. | Uncharacterized protein YCL048W-A; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCL048W-A has a paralog, YDR524C-B, that arose from the whole genome duplication. | 0.766 |
YBR230W-A | YIL002W-A | YBR230W-A | YIL002W-A | Putative protein of unknown function; YBR230W-A has a paralog, COQ8, that arose from the whole genome duplication. | Uncharacterized protein YIL002W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry. | 0.763 |
YCL048W-A | CAR2 | YCL048W-A | YLR438W | Uncharacterized protein YCL048W-A; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCL048W-A has a paralog, YDR524C-B, that arose from the whole genome duplication. | L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant. | 0.404 |
YCL048W-A | FMP45 | YCL048W-A | YDL222C | Uncharacterized protein YCL048W-A; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCL048W-A has a paralog, YDR524C-B, that arose from the whole genome duplication. | SUR7 family protein FMP45; Integral membrane protein localized to mitochondria; required for sporulation and maintaining sphingolipid content; similar to SUR7; FMP45 has a paralog, YNL194C, that arose from the whole genome duplication. | 0.550 |