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IRC8 protein (Saccharomyces cerevisiae) - STRING interaction network
"IRC8" - Bud tip localized protein of unknown function in Saccharomyces cerevisiae
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
IRC8Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc (822 aa)    
Predicted Functional Partners:
SHE2
RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Recruits the MYO4-SHE3 complex to the ASH1 mRNA. Recruits also LOC1 and PUF6 to ASH1 mRNA, which are required for translational repression of this mRNA (246 aa)
       
 
  0.877
RPL38
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein (78 aa)
       
      0.699
YLL032C
Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene (825 aa)
       
      0.699
KSH1
Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; ortholog of human Kish; Involved in the early part of the secretory pathway (72 aa)
           
  0.485
YDL071C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W (124 aa)
           
  0.470
IRC24
Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci; Reduces benzil stereospecifically to (S)-benzoin. Is probably involved in a pathway contributing to genomic integrity (263 aa)
           
  0.448
YML053C
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene (212 aa)
           
  0.443
IRC6
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; Involved in gross chromosomal rearrangements (GCRs) and telomere healing (237 aa)
           
  0.441
MTC6
Protein of unknown function; mtc6 is synthetically sick with cdc13-1; May be involved in telomere capping (526 aa)
           
  0.418
URN1
Protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase; Component of the spliceosome involved in mRNA processing (465 aa)
           
  0.416
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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