STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
YJL052C-AUncharacterized protein YJL052C-A; Putative protein of unknown function; identified based on comparison to related yeast species; mCherry fusion protein localizes to the vacuole (39 aa)    
Predicted Functional Partners:
YOR268C
Uncharacterized protein YOR268C; Putative protein of unknown function; sporulation is abnormal in homozygous diploid; SWAT-GFP fusion protein localizes to the nucleus; YOR268C is not an essential gene
      
 0.896
SPE4
Spermine synthase; required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
      
 0.717
YBR225W
Uncharacterized protein YBR225W; Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components
      
 0.634
DSC2
Uncharacterized membrane protein YOL073C; Multi-transmembrane subunit of the DSC ubiquitin ligase complex; similar in sequence to rhomboid pseudoproteases Der1p and UBAC2 that function in ERAD; ortholog of fission yeast dsc2
      
 0.615
YLR345W
Bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase; Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W; Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene; In the C-terminal section; belongs to the phosphoglycerate mutase family
      
 0.555
MRPS9
Mitochondrial 37s ribosomal protein mrps9; Mitochondrial ribosomal protein of the small subunit
      
 0.450
PRM7
Pheromone-regulated protein; predicted to have one transmembrane segment; promoter contains Gcn4p binding elements; in W303 strain one continuous open reading frame comprising of YDL037C, the intergenic region and YDL039C encodes the IMI1
      
 0.450
YGL117W
Uncharacterized protein YGL117W; Putative protein of unknown function
      
 0.450
GPA1
Guanine nucleotide-binding protein alpha-1 subunit; Subunit of the G protein involved in pheromone response; GTP-binding alpha subunit of the heterotrimeric G protein; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome; protein abundance increases in response to DNA replication stress
      
 0.450
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.