node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COY1 | MTC1 | YKL179C | YJL123C | Homeobox protein cut-like; Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function | Maintenance of telomere capping protein 1; Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 | 0.775 |
CRP1 | FYV8 | YHR146W | YGR196C | Cruciform dna-recognizing protein 1; Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication | Protein fyv8; Protein of unknown function; required for survival upon exposure to K1 killer toxin | 0.691 |
CRP1 | MRH1 | YHR146W | YDR033W | Cruciform dna-recognizing protein 1; Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication | Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; null mutation confers sensitivity to acetic acid; Belongs to the archaeal/bacterial/fungal opsin family | 0.450 |
CRP1 | MTC1 | YHR146W | YJL123C | Cruciform dna-recognizing protein 1; Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication | Maintenance of telomere capping protein 1; Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 | 0.718 |
CRP1 | SKS1 | YHR146W | YPL026C | Cruciform dna-recognizing protein 1; Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication | Serine/threonine-protein kinase SKS1; Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway; SKS1 has a paralog, VHS1, that arose from the whole genome duplication | 0.682 |
CRP1 | YJL118W | YHR146W | YJL118W | Cruciform dna-recognizing protein 1; Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication | Uncharacterized protein YJL118W; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL118W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein | 0.712 |
CRP1 | YMR196W | YHR146W | YMR196W | Cruciform dna-recognizing protein 1; Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication | Uncharacterized protein YMR196W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene | 0.876 |
FYV8 | CRP1 | YGR196C | YHR146W | Protein fyv8; Protein of unknown function; required for survival upon exposure to K1 killer toxin | Cruciform dna-recognizing protein 1; Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication | 0.691 |
FYV8 | MRH1 | YGR196C | YDR033W | Protein fyv8; Protein of unknown function; required for survival upon exposure to K1 killer toxin | Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; null mutation confers sensitivity to acetic acid; Belongs to the archaeal/bacterial/fungal opsin family | 0.617 |
FYV8 | MTC1 | YGR196C | YJL123C | Protein fyv8; Protein of unknown function; required for survival upon exposure to K1 killer toxin | Maintenance of telomere capping protein 1; Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 | 0.820 |
FYV8 | SKS1 | YGR196C | YPL026C | Protein fyv8; Protein of unknown function; required for survival upon exposure to K1 killer toxin | Serine/threonine-protein kinase SKS1; Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway; SKS1 has a paralog, VHS1, that arose from the whole genome duplication | 0.613 |
FYV8 | YMR196W | YGR196C | YMR196W | Protein fyv8; Protein of unknown function; required for survival upon exposure to K1 killer toxin | Uncharacterized protein YMR196W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene | 0.712 |
GCD14 | MTC1 | YJL125C | YJL123C | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family | Maintenance of telomere capping protein 1; Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 | 0.698 |
GCD14 | YJL118W | YJL125C | YJL118W | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family | Uncharacterized protein YJL118W; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL118W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein | 0.691 |
GET4 | MTC1 | YOR164C | YJL123C | Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20 | Maintenance of telomere capping protein 1; Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 | 0.918 |
MRH1 | CRP1 | YDR033W | YHR146W | Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; null mutation confers sensitivity to acetic acid; Belongs to the archaeal/bacterial/fungal opsin family | Cruciform dna-recognizing protein 1; Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication | 0.450 |
MRH1 | FYV8 | YDR033W | YGR196C | Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; null mutation confers sensitivity to acetic acid; Belongs to the archaeal/bacterial/fungal opsin family | Protein fyv8; Protein of unknown function; required for survival upon exposure to K1 killer toxin | 0.617 |
MRH1 | MTC1 | YDR033W | YJL123C | Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; null mutation confers sensitivity to acetic acid; Belongs to the archaeal/bacterial/fungal opsin family | Maintenance of telomere capping protein 1; Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 | 0.700 |
MRH1 | SKS1 | YDR033W | YPL026C | Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; null mutation confers sensitivity to acetic acid; Belongs to the archaeal/bacterial/fungal opsin family | Serine/threonine-protein kinase SKS1; Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway; SKS1 has a paralog, VHS1, that arose from the whole genome duplication | 0.454 |
MRH1 | YMR196W | YDR033W | YMR196W | Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; null mutation confers sensitivity to acetic acid; Belongs to the archaeal/bacterial/fungal opsin family | Uncharacterized protein YMR196W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene | 0.714 |