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PRP21 protein (Saccharomyces cerevisiae) - STRING interaction network
"PRP21" - Subunit of the SF3a splicing factor complex, required for spliceosome assembly in Saccharomyces cerevisiae
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PRP21Subunit of the SF3a splicing factor complex, required for spliceosome assembly; mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for binding of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly (280 aa)    
Predicted Functional Partners:
PRP9
Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex; mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for binding of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly (530 aa)
     
 
  0.999
PRP11
Subunit of the SF3a splicing factor complex, required for spliceosome assembly; mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for addition of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly (266 aa)
     
 
  0.999
PRP19
Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain; Probable ubiquitin-protein ligase involved in pre-mRNA splicing. Acts as a central component of the NTC complex (or PRP19-associated complex) that associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. It is also probably involved in DNA repair (503 aa)
     
 
  0.999
PRP6
Splicing factor, component of the U4/U6-U5 snRNP complex; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (899 aa)
     
 
  0.998
CEF1
Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p; Involved in pre-mRNA splicing and cell cycle control. Required for the binding of the NTC complex (or PRP19-associated complex) components to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. Its absence leads to an arrest of the c [...] (590 aa)
     
 
  0.998
HSH49
U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM); Possible SF3b-like factor (213 aa)
     
 
  0.992
PRP4
Splicing factor, component of the U4/U6-U5 snRNP complex; Involved in RNA splicing. Is required for the association of U4/U6 snRNP with U5 snRNP in an early step of spliceosome assembly (465 aa)
     
 
  0.988
CUS1
Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p; Essential splicing protein required for U2 snRNP binding to pre-mRNA during spliceosome assembly (436 aa)
     
 
  0.986
PRP46
Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; Involved in pre-mRNA splicing. May also be required for cell cycle progression at G2/M (By similarity) (451 aa)
     
 
  0.983
LEA1
Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A’ snRNP protein; Involved in pre-mRNA splicing. Associates to U2 snRNA in a MSL1 dependent manner and is required for normal accumulation of U2 snRNA. Required for the spliceosome assembly and the efficient addition of U2 snRNP onto the pre-mRNA (238 aa)
     
 
  0.981
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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