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CCE1 protein (Saccharomyces cerevisiae) - STRING interaction network
"CCE1" - Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA in Saccharomyces cerevisiae
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CCE1Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA; Capable of resolving Holliday junctions. Specific for 4- way junctions. Seems to be important for the maintenance of mitochondrial DNA. Cleaves fixed junctions at the point of strand exchange. Cleaves after 5’-CT-3’ sequence (353 aa)    
Predicted Functional Partners:
MHR1
Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress; Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells (226 aa)
       
 
  0.927
MSH1
DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis; Important for mitochondrial DNA (mtDNA) stability and repair. Recognizes and binds to base-base and small insertion- deletion mismatches in mtDNA. ATP binding and hydrolysis is crucial for function. Binding to a mismatched base pair attenuates ATP hydrolysis. Also involved in proper sorting of mtDNA during mtDNA transmission (959 aa)
       
 
  0.841
ABF2
Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation; Specific binding to the autonomously replicating sequence 1 (ARS1). Interaction with regulatory regions- probably involved in compacting the mitochondrial genome. It might play a positive role in gene expression and replication (183 aa)
       
 
  0.763
SLX1
Subunit of a complex, with Slx4p, that hydrolyzes 5’ branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for simple Y, 5’-flap and replication fork-like structures. It cleaves the strand bearing the 5’-non-homolog [...] (304 aa)
           
  0.697
DIN7
Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination; 5’->3’ double-stranded DNA exonuclease (430 aa)
           
  0.626
ORI5
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data (46 aa)
           
  0.540
YOR282W
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C (106 aa)
           
  0.512
HMI1
Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD; Required for mitochondrial genome maintenance and mitochondrial DNA inheritance (706 aa)
           
  0.487
RNH1
Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (348 aa)
           
  0.425
PIF1
DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; DNA-dependent ATPase and 5’-3’ DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Appears to move along DNA in single nucleotide or base pair steps, powered by hydrolysis of 1 molecule of ATP. Processes at an unwinding rate of about 75 bp/s. Resolv [...] (859 aa)
           
  0.418
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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