node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIM26 | AIM44 | YKL037W | YPL158C | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | Altered inheritance of mitochondria protein 44; Protein that regulates Cdc42p and Rho1p; functions in the late steps of cytokinesis and cell separation; sustains Rho1p at the cell division site after actomyosin ring contraction; inhibits the activation of Cdc42-Cla4 at the cell division site to prevent budding inside the old bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress. | 0.416 |
AIM26 | KRE1 | YKL037W | YNL322C | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor. | 0.473 |
AIM26 | MRPL25 | YKL037W | YGR076C | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan. | 0.412 |
AIM26 | SMI1 | YKL037W | YGR229C | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | Cell wall assembly regulator SMI1; Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity. | 0.450 |
AIM26 | SML1 | YKL037W | YML058W | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome duplication. | 0.420 |
AIM26 | YGL072C | YKL037W | YGL072C | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | Putative uncharacterized protein YGL072C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2. | 0.762 |
AIM26 | YGL235W | YKL037W | YGL235W | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | Uncharacterized protein YGL235W; Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2. | 0.701 |
AIM26 | YLR456W | YKL037W | YLR456W | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | Pyridoxamine 5'-phosphate oxidase YLR456W homolog; Protein of unknown function; predicted to encode a pyridoxal 5'-phosphate synthase based on sequence similarity but purified protein does not possess this activity, nor does it bind flavin mononucleotide (FMN); null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication. | 0.516 |
AIM26 | YOR345C | YKL037W | YOR345C | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | Putative uncharacterized protein YOR345C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2. | 0.693 |
AIM44 | AIM26 | YPL158C | YKL037W | Altered inheritance of mitochondria protein 44; Protein that regulates Cdc42p and Rho1p; functions in the late steps of cytokinesis and cell separation; sustains Rho1p at the cell division site after actomyosin ring contraction; inhibits the activation of Cdc42-Cla4 at the cell division site to prevent budding inside the old bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress. | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | 0.416 |
AIM44 | SMI1 | YPL158C | YGR229C | Altered inheritance of mitochondria protein 44; Protein that regulates Cdc42p and Rho1p; functions in the late steps of cytokinesis and cell separation; sustains Rho1p at the cell division site after actomyosin ring contraction; inhibits the activation of Cdc42-Cla4 at the cell division site to prevent budding inside the old bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress. | Cell wall assembly regulator SMI1; Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity. | 0.413 |
KRE1 | AIM26 | YNL322C | YKL037W | Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor. | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | 0.473 |
KRE1 | SMI1 | YNL322C | YGR229C | Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor. | Cell wall assembly regulator SMI1; Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity. | 0.810 |
MRPL25 | AIM26 | YGR076C | YKL037W | Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan. | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | 0.412 |
SMI1 | AIM26 | YGR229C | YKL037W | Cell wall assembly regulator SMI1; Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity. | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | 0.450 |
SMI1 | AIM44 | YGR229C | YPL158C | Cell wall assembly regulator SMI1; Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity. | Altered inheritance of mitochondria protein 44; Protein that regulates Cdc42p and Rho1p; functions in the late steps of cytokinesis and cell separation; sustains Rho1p at the cell division site after actomyosin ring contraction; inhibits the activation of Cdc42-Cla4 at the cell division site to prevent budding inside the old bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress. | 0.413 |
SMI1 | KRE1 | YGR229C | YNL322C | Cell wall assembly regulator SMI1; Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity. | Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor. | 0.810 |
SML1 | AIM26 | YML058W | YKL037W | Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome duplication. | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | 0.420 |
YGL072C | AIM26 | YGL072C | YKL037W | Putative uncharacterized protein YGL072C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2. | Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT. | 0.762 |
YGL072C | YGL235W | YGL072C | YGL235W | Putative uncharacterized protein YGL072C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2. | Uncharacterized protein YGL235W; Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2. | 0.908 |