node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADH6 | ARI1 | YMR318C | YGL157W | NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress. | NADPH-dependent aldehyde reductase; utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily. | 0.851 |
ADH6 | YDR541C | YMR318C | YDR541C | NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress. | Putative uncharacterized oxidoreductase YDR541C; Aldehyde reductase; substrates include both aromatic and aliphatic aldehydes; uses NADPH as cofactor; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily. | 0.623 |
ADH6 | YGL039W | YMR318C | YGL039W | NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress. | Putative uncharacterized oxidoreductase YGL039W; Aldehyde reductase; reduces aliphatic aldehyde substrates using NADH as cofactor; shown to reduce carbonyl compounds to chiral alcohols. | 0.576 |
ADH6 | YKL107W | YMR318C | YKL107W | NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress. | Uncharacterized oxidoreductase YKL107W; Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein. | 0.584 |
ADH6 | YLL056C | YMR318C | YLL056C | NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress. | Uncharacterized protein YLL056C; Putative protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively. | 0.421 |
ADH6 | YNL134C | YMR318C | YNL134C | NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress. | Uncharacterized protein YNL134C; NADH-dependent aldehyde reductase, involved in detoxification of furfural; expression is up-regulated in the presence of furfural and 5-hydroxymethylfurfural, which are compounds generated during lignocellulosic biomass pre-treatment; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress. | 0.677 |
ARI1 | ADH6 | YGL157W | YMR318C | NADPH-dependent aldehyde reductase; utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily. | NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress. | 0.851 |
ARI1 | YKL107W | YGL157W | YKL107W | NADPH-dependent aldehyde reductase; utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily. | Uncharacterized oxidoreductase YKL107W; Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein. | 0.639 |
ARI1 | YNL134C | YGL157W | YNL134C | NADPH-dependent aldehyde reductase; utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily. | Uncharacterized protein YNL134C; NADH-dependent aldehyde reductase, involved in detoxification of furfural; expression is up-regulated in the presence of furfural and 5-hydroxymethylfurfural, which are compounds generated during lignocellulosic biomass pre-treatment; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress. | 0.400 |
DCI1 | YGR153W | YOR180C | YGR153W | Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed; DCI1 has a paralog, ECI1, that arose from the whole genome duplication. | Uncharacterized protein YGR153W; Putative protein of unknown function. | 0.449 |
DCI1 | YKL107W | YOR180C | YKL107W | Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed; DCI1 has a paralog, ECI1, that arose from the whole genome duplication. | Uncharacterized oxidoreductase YKL107W; Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein. | 0.609 |
YDR541C | ADH6 | YDR541C | YMR318C | Putative uncharacterized oxidoreductase YDR541C; Aldehyde reductase; substrates include both aromatic and aliphatic aldehydes; uses NADPH as cofactor; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily. | NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress. | 0.623 |
YDR541C | YKL107W | YDR541C | YKL107W | Putative uncharacterized oxidoreductase YDR541C; Aldehyde reductase; substrates include both aromatic and aliphatic aldehydes; uses NADPH as cofactor; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily. | Uncharacterized oxidoreductase YKL107W; Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein. | 0.630 |
YDR541C | YNL134C | YDR541C | YNL134C | Putative uncharacterized oxidoreductase YDR541C; Aldehyde reductase; substrates include both aromatic and aliphatic aldehydes; uses NADPH as cofactor; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily. | Uncharacterized protein YNL134C; NADH-dependent aldehyde reductase, involved in detoxification of furfural; expression is up-regulated in the presence of furfural and 5-hydroxymethylfurfural, which are compounds generated during lignocellulosic biomass pre-treatment; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress. | 0.480 |
YGL039W | ADH6 | YGL039W | YMR318C | Putative uncharacterized oxidoreductase YGL039W; Aldehyde reductase; reduces aliphatic aldehyde substrates using NADH as cofactor; shown to reduce carbonyl compounds to chiral alcohols. | NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress. | 0.576 |
YGL039W | YKL107W | YGL039W | YKL107W | Putative uncharacterized oxidoreductase YGL039W; Aldehyde reductase; reduces aliphatic aldehyde substrates using NADH as cofactor; shown to reduce carbonyl compounds to chiral alcohols. | Uncharacterized oxidoreductase YKL107W; Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein. | 0.806 |
YGL039W | YLL056C | YGL039W | YLL056C | Putative uncharacterized oxidoreductase YGL039W; Aldehyde reductase; reduces aliphatic aldehyde substrates using NADH as cofactor; shown to reduce carbonyl compounds to chiral alcohols. | Uncharacterized protein YLL056C; Putative protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively. | 0.450 |
YGL039W | YNL134C | YGL039W | YNL134C | Putative uncharacterized oxidoreductase YGL039W; Aldehyde reductase; reduces aliphatic aldehyde substrates using NADH as cofactor; shown to reduce carbonyl compounds to chiral alcohols. | Uncharacterized protein YNL134C; NADH-dependent aldehyde reductase, involved in detoxification of furfural; expression is up-regulated in the presence of furfural and 5-hydroxymethylfurfural, which are compounds generated during lignocellulosic biomass pre-treatment; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress. | 0.430 |
YGR153W | DCI1 | YGR153W | YOR180C | Uncharacterized protein YGR153W; Putative protein of unknown function. | Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed; DCI1 has a paralog, ECI1, that arose from the whole genome duplication. | 0.449 |
YGR153W | YJL045W | YGR153W | YJL045W | Uncharacterized protein YGR153W; Putative protein of unknown function. | Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial; Minor succinate dehydrogenase isozyme; participates in oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; YJL045W has a paralog, SDH1, that arose from the whole genome duplication. | 0.487 |