STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RRN3Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo; Belongs to the RRN3 family (627 aa)    
Predicted Functional Partners:
RPA43
RNA polymerase I subunit A43; Belongs to the eukaryotic RPA43 RNA polymerase subunit family
   
 0.999
RPA190
Dna-directed rna polymerase i core subunit rpa190; RNA polymerase I largest subunit A190; Belongs to the RNA polymerase beta' chain family
   
 0.999
RPA135
Dna-directed rna polymerase i core subunit rpa135; RNA polymerase I second largest subunit A135
   
 0.999
RRN7
RNA polymerase I-specific transcription initiation factor RRN7; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p; Belongs to the RRN7/TAF1B family
   
 0.998
RPA49
RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p
   
 0.996
RRN6
RNA polymerase I-specific transcription initiation factor RRN6; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
    
 
 0.994
RPC40
RNA polymerase subunit AC40; common to RNA polymerase I and III; predominant determinant targeting Ty1 integration upstream of Pol III-transcribed genes
   
 0.994
RPC19
Dna-directed rna polymerases i and iii subunit rpac2; RNA polymerase subunit AC19; common to RNA polymerases I and III
    
 
 0.991
RPA12
RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family
   
 0.989
SPT15
TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP
   
 0.985
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.