node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG8 | YKR051W | YBL078C | YKR051W | Autophagy-related protein 8; Component of autophagosomes and Cvt vesicles; regulator of Atg1p, targets it to autophagosomes; binds the Atg1p-Atg13p complex, triggering its vacuolar degradation; unique ubiquitin-like protein whose conjugation target is lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis. | Transmembrane protein 184 homolog YKR051W; Putative protein of unknown function. | 0.977 |
DLD2 | YKR051W | YDL178W | YKR051W | D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2; D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate with a minor role in lactate catabolism; located in the mitochondrial matrix; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. | Transmembrane protein 184 homolog YKR051W; Putative protein of unknown function. | 0.420 |
NCR1 | YKR051W | YPL006W | YKR051W | NPC intracellular sterol transporter 1-related protein 1; Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p; Belongs to the patched family. | Transmembrane protein 184 homolog YKR051W; Putative protein of unknown function. | 0.403 |
SDC1 | YKR051W | YDR469W | YKR051W | COMPASS component SDC1; Subunit of the COMPASS (Set1C) complex; COMPASS methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30. | Transmembrane protein 184 homolog YKR051W; Putative protein of unknown function. | 0.658 |
SEC2 | YKR051W | YNL272C | YKR051W | Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles; Belongs to the SEC2 family. | Transmembrane protein 184 homolog YKR051W; Putative protein of unknown function. | 0.465 |
UBC9 | YKR051W | YDL064W | YKR051W | SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC). | Transmembrane protein 184 homolog YKR051W; Putative protein of unknown function. | 0.891 |
YKR051W | ATG8 | YKR051W | YBL078C | Transmembrane protein 184 homolog YKR051W; Putative protein of unknown function. | Autophagy-related protein 8; Component of autophagosomes and Cvt vesicles; regulator of Atg1p, targets it to autophagosomes; binds the Atg1p-Atg13p complex, triggering its vacuolar degradation; unique ubiquitin-like protein whose conjugation target is lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis. | 0.977 |
YKR051W | DLD2 | YKR051W | YDL178W | Transmembrane protein 184 homolog YKR051W; Putative protein of unknown function. | D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2; D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate with a minor role in lactate catabolism; located in the mitochondrial matrix; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. | 0.420 |
YKR051W | NCR1 | YKR051W | YPL006W | Transmembrane protein 184 homolog YKR051W; Putative protein of unknown function. | NPC intracellular sterol transporter 1-related protein 1; Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p; Belongs to the patched family. | 0.403 |
YKR051W | SDC1 | YKR051W | YDR469W | Transmembrane protein 184 homolog YKR051W; Putative protein of unknown function. | COMPASS component SDC1; Subunit of the COMPASS (Set1C) complex; COMPASS methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30. | 0.658 |
YKR051W | SEC2 | YKR051W | YNL272C | Transmembrane protein 184 homolog YKR051W; Putative protein of unknown function. | Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles; Belongs to the SEC2 family. | 0.465 |
YKR051W | UBC9 | YKR051W | YDL064W | Transmembrane protein 184 homolog YKR051W; Putative protein of unknown function. | SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC). | 0.891 |