node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACT1 | BEM2 | YFL039C | YER155C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | GTPase-activating protein BEM2/IPL2; Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p. | 0.798 |
ACT1 | CDC42 | YFL039C | YLR229C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Cell division control protein 42; Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; mutants have defects in the organization of actin and septins; human homolog CDC42 can complement yeast cdc42 mutant. | 0.989 |
ACT1 | CYK3 | YFL039C | YDL117W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants. | 0.614 |
ACT1 | HOF1 | YFL039C | YMR032W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Cytokinesis protein 2; Protein that regulates actin cytoskeleton organization; required for cytokinesis, actin cable organization, and secretory vesicle trafficking; localized to bud neck; phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; contains an SH3 domain; N terminus controls cell size and levels of actin cables, while C terminus controls actin cable organization via direct regulation of the formin Bnr1p. | 0.928 |
ACT1 | INN1 | YFL039C | YNL152W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Ingression protein 1; Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis. | 0.646 |
ACT1 | PXL1 | YFL039C | YKR090W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Paxillin-like protein 1; Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress. | 0.674 |
ACT1 | RGA1 | YFL039C | YOR127W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; RGA1 has a paralog, RGA2, that arose from the whole genome duplication. | 0.679 |
ACT1 | RGD1 | YFL039C | YBR260C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; possibly involved in control of actin cytoskeleton organization. | 0.629 |
ACT1 | RHO1 | YFL039C | YPR165W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | GTP-binding protein of the rho subfamily of Ras-like proteins; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p). | 0.978 |
ACT1 | RHO2 | YFL039C | YNL090W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | GTP-binding protein RHO2; Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity and in microtubule assembly. | 0.771 |
BEM2 | ACT1 | YER155C | YFL039C | GTPase-activating protein BEM2/IPL2; Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p. | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | 0.798 |
BEM2 | CDC42 | YER155C | YLR229C | GTPase-activating protein BEM2/IPL2; Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p. | Cell division control protein 42; Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; mutants have defects in the organization of actin and septins; human homolog CDC42 can complement yeast cdc42 mutant. | 0.988 |
BEM2 | HOF1 | YER155C | YMR032W | GTPase-activating protein BEM2/IPL2; Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p. | Cytokinesis protein 2; Protein that regulates actin cytoskeleton organization; required for cytokinesis, actin cable organization, and secretory vesicle trafficking; localized to bud neck; phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; contains an SH3 domain; N terminus controls cell size and levels of actin cables, while C terminus controls actin cable organization via direct regulation of the formin Bnr1p. | 0.500 |
BEM2 | INN1 | YER155C | YNL152W | GTPase-activating protein BEM2/IPL2; Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p. | Ingression protein 1; Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis. | 0.495 |
BEM2 | PXL1 | YER155C | YKR090W | GTPase-activating protein BEM2/IPL2; Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p. | Paxillin-like protein 1; Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress. | 0.604 |
BEM2 | RGA1 | YER155C | YOR127W | GTPase-activating protein BEM2/IPL2; Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p. | GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; RGA1 has a paralog, RGA2, that arose from the whole genome duplication. | 0.860 |
BEM2 | RGD1 | YER155C | YBR260C | GTPase-activating protein BEM2/IPL2; Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p. | GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; possibly involved in control of actin cytoskeleton organization. | 0.662 |
BEM2 | RHO1 | YER155C | YPR165W | GTPase-activating protein BEM2/IPL2; Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p. | GTP-binding protein of the rho subfamily of Ras-like proteins; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p). | 0.991 |
BEM2 | RHO2 | YER155C | YNL090W | GTPase-activating protein BEM2/IPL2; Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p. | GTP-binding protein RHO2; Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity and in microtubule assembly. | 0.806 |
CDC42 | ACT1 | YLR229C | YFL039C | Cell division control protein 42; Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; mutants have defects in the organization of actin and septins; human homolog CDC42 can complement yeast cdc42 mutant. | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | 0.989 |