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ADD37 protein (Saccharomyces cerevisiae) - STRING interaction network
"ADD37" - Protein of unknown function involved in ER-associated protein degradation in Saccharomyces cerevisiae
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ADD37Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; Involved in ER-associated protein degradation (ERAD) (198 aa)    
Predicted Functional Partners:
YBR285W
Putative protein of unknown function; YBR285W is not an essential gene (144 aa)
           
  0.697
YMR141C
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (102 aa)
           
  0.578
YNR005C
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (134 aa)
           
  0.518
MLF3
Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide (452 aa)
           
  0.481
MPD1
Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation; Participates in the folding of proteins containing disulfide bonds (318 aa)
     
   
  0.445
YBR138C
Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene (524 aa)
           
  0.441
DOG2
2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; Active on 2-DOG-6P, not very active on fructose-1p (246 aa)
     
   
  0.438
DER1
Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p; Component of the endoplasmic reticulum-associated degradation (ERAD) pathway. Specifically required for the ERAD-L pathway which mediates the degradation of proteins with misfolded lumenal domains within the endoplasmic reticulum (211 aa)
     
   
  0.433
YDL172C
Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data (159 aa)
           
  0.416
OSW5
Protein of unknown function with possible role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion; Involved in spore wall assembly (148 aa)
           
  0.414
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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